Association Between BDNF Val66Met Polymorphism and Cognitive Performance in Antipsychotic-Naive Patients with Schizophrenia
Association Between BDNF Val66Met Polymorphism and Cognitive Performance in Antipsychotic-Naive Patients with Schizophrenia
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BDNF Val66Met 多态性与未接受抗精神病药物治疗的精神分裂症患者认知表现之间的关联
DOI：
10.1007/s12031-012-9750-4
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发表时间：
2012-07-01
影响因子：
3.1
通讯作者：
Fang, Yiru
中科院分区：
文献类型：
--
作者：
Lu, Weihong;Zhang, Chen;Fang, Yiru
认知障碍是精神分裂症的核心症状之一，反映了精神分裂症病因学上的神经发育缺陷。脑源性神经营养因子(BDNF)在多种神经发育过程中发挥重要作用。越来越多的证据表明，脑源性神经营养因子可能与精神分裂症的病因有关。本研究旨在探讨脑源性神经营养因子Val66Met基因多态性与精神分裂症患者认知功能的关系。采用韦氏成人智力量表修订版、韦氏记忆量表修订版和威斯康星卡片分类测验(WCST)对112例精神分裂症患者和63例健康对照进行神经心理测试。我们检测了112名患者和394名对照的Val66Met基因多态性。比较Met等位基因携带者与非Met等位基因携带者的认知功能。与对照组相比，精神分裂症患者存在广泛的认知障碍(P<；0.01)。患者组和对照组之间的基因和等位基因分布均无显著差异。携带Met等位基因的患者持续错误百分比明显高于不携带Met等位基因的患者(P=0.007)。按性别分层后，男性患者Met等位基因与持久性错误的比例较高(P=0.014.0 5)，而女性患者无关联(P=0.0 9)。精神分裂症患者的认知能力普遍受损。BDNF Val66Met基因多态可能与执行功能受损有关。这种影响可能具有性别特有的特征。
Cognitive impairment is one of the core symptoms in schizophrenia, which reflects the neurodevelopmental deficits in the etiology of this disease. Brain-derived neurotrophic factor (BDNF) plays an important role in various neurodevelopmental processes. Growing evidence has shown that BDNF may be involved in the etiology of schizophrenia. The aim of this study was to examine the association of the BDNF Val66Met polymorphism with cognition in patients with schizophrenia. Various neuropsychological tests including the Wechsler Adult Intelligence Scale-Revised, the Wechsler Memory Scale-Revised, and the Wisconsin Card Sorting Test (WCST) were employed in a sample of 112 antipsychotic-na < ve patients with schizophrenia and 63 healthy controls. We examined the Val66Met polymorphism in the 112 patients and 394 controls. Among the patients, cognition was compared between Met allele carriers and non-Met allele carriers. A wide range of cognitive deficits were demonstrated in the schizophrenic patients, compared with the controls (Ps < 0.01). No significant differences of genotype or allele distribution were identified between patients and controls. The patients with Met allele showed more percent WCST perseverative errors than those without Met allele (P = 0.007). After stratification based on gender, an association between the Met allele and a higher percentage of perseverative errors was found in male patients (P = 0.014), but not in females (P = 0.09). Cognitive performance is broadly impaired in schizophrenic patients. The BDNF Val66Met polymorphism may be involved in the impaired executive function. This effect may have gender-specific characteristics.