Herpes Simplex Virus 1 Deregulation of Host MicroRNAs
Herpes Simplex Virus 1 Deregulation of Host MicroRNAs
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DOI：
10.3390/ncrna4040036
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发表时间：
2018-12-01
期刊：
影响因子：
4.3
通讯作者：
Jurak, Igor
中科院分区：
文献类型：
--
作者：
Brdovcak, Maja Cokaric;Zubkovic, Andreja;Jurak, Igor
病毒在各种可能的相互作用和机制中利用microRNAs（miRNAs），显然远远超出了对人类基因抑制的经典理解。类似地，单纯疱疹病毒1（HSV-1）表达许多miRNA并使宿主miRNA的表达失调。几种HSV-1 miRNA在潜伏期大量表达，其中一些与重要的生产性感染基因的转录物反义编码，表明它们在抑制生产周期和/或维持/从潜伏期重新激活中的作用。此外，HSV-1还利用宿主miRNA来促进其复制或抑制其基因以促进潜伏期。在这里，我们讨论了HSV-1和宿主miRNA机制之间的功能相互作用，潜在的靶标以及导致有效病毒复制和传播的分子机制。
Viruses utilize microRNAs (miRNAs) in a vast variety of possible interactions and mechanisms, apparently far beyond the classical understanding of gene repression in humans. Likewise, herpes simplex virus 1 (HSV-1) expresses numerous miRNAs and deregulates the expression of host miRNAs. Several HSV-1 miRNAs are abundantly expressed in latency, some of which are encoded antisense to transcripts of important productive infection genes, indicating their roles in repressing the productive cycle and/or in maintenance/reactivation from latency In addition, HSV-1 also exploits host miRNAs to advance its replication or repress its genes to facilitate latency. Here, we discuss what is known about the functional interplay between HSV-1 and the host miRNA machinery, potential targets, and the molecular mechanisms leading to an efficient virus replication and spread.