CATALYTIC ANTIBODIES WITH LIPASE ACTIVITY AND R-SUBSTRATE OR S-SUBSTRATE SELECTIVITY
CATALYTIC ANTIBODIES WITH LIPASE ACTIVITY AND R-SUBSTRATE OR S-SUBSTRATE SELECTIVITY
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DOI：
10.1126/science.2717936
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发表时间：
1989-04-28
期刊：
影响因子：
56.9
通讯作者：
LERNER, RA
中科院分区：
文献类型：
--
作者：
JANDA, KD;BENKOVIC, SJ;LERNER, RA
带有 R 或 S 对映体醇的未活化酯的特异性水解是通过诱导结合 R 或 S 底物的两类不同类别的催化抗体实现的。这些抗体表现出高于背景水解的速率加速（103 至 105），再加上它们的反足特异性，提供了一组用于合成的新型试剂。
The specific hydrolysis of unactivated esters bearing an R or S enantiomeric alcohol has been achieved by two separate classes of catalytic antibodies induced to bind either the R or S substrates. The antibodies exhibit rate accelerations (103 to 105) above background hydrolysis that, coupled with their antipodal specificity, provide a novel set of reagnets for use in synthesis.