Role of secretory leukocyte protease inhibitor in the development of subclinical emphysema
Role of secretory leukocyte protease inhibitor in the development of subclinical emphysema
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DOI：
10.1183/09031936.02.00253202
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发表时间：
2002-06-01
影响因子：
24.3
通讯作者：
Nishimura, M
中科院分区：
文献类型：
--
作者：
Betsuyaku, T;Takeyabu, K;Nishimura, M
分泌性白细胞蛋白酶抑制剂（SLPI）是人类白细胞弹性蛋白酶的有效抑制剂。在一些慢性气道疾病中，痰中SLPI水平降低，导致中性粒细胞炎症持续。本研究探讨了SLPI在亚临床肺气肿中的作用。通过序贯支气管肺泡灌洗，试图分别评估两组吸烟者大气道和外周气道中SLPI的水平。通过计算机断层扫描检查，一组有亚临床肺气肿，另一组则没有。还评估了肺泡巨噬细胞 (AM) 中的 SLPI。与肺气肿患者相比，肺气肿患者外周气道中的 SLPI 水平显着升高。无肺气肿（1589.2 +/- 353.9 与 729.1 +/- 31.0 ng.mL(-1)），尽管大气道中的情况相似（3442.3+/-499.6 与 2535.7 +/- 578.8 ng.mL(-1)）。在亚临床肺气肿受试者中，AM 中释放出的 SLPI 量有较高的趋势，但未达到统计学意义。 总之，亚临床肺气肿患者外周气道中分泌性白细胞蛋白酶抑制剂存在代偿性上调，这与一些慢性气道疾病中报道的分泌性白细胞蛋白酶抑制剂水平下降形成鲜明对比。
Secretory leukocyte protease inhibitor (SLPI) is a potent inhibitor of human leukocyte elastase. In some chronic airway diseases, the level of SLPI is decreased in sputum, leading to the continuation of neutrophil inflammation. In this study, the role of SLPI in subclinical pulmonary emphysema was examined.Sequential bronchoalveolar lavage was performed in an attempt to separately evaluate the levels of SLPI in the large airway's and in the peripheral airways for two groups of smokers. One group had subclinical emphysema by computed-tomography scans and one group did not. SLPI localized in alveolar macrophages (AM) was also assessed.The level of SLPI was significantly elevated in the peripheral airways from the subjects with emphysema compared to those. without emphysema (1589.2 +/- 353.9 versus 729.1 +/- 31.0 ng.mL(-1)) although it was similar in the large airways (3442.3+/-499.6 versus 2535.7 +/- 578.8 ng.mL(-1)). There was a trend for higher amount of SLPI to be released from AM in subjects with subclinical emphysema, although this did not reach statistical significance.In conclusion, there is compensatory upregulation of secretory leukocyte protease inhibitor in peripheral airways in subclinical pulmonary emphysema, which is in sharp contrast to the decreased level of secretory leukocyte protease inhibitor reported in some chronic airway diseases.