CORTICAL DISTRIBUTION OF GANGLIOSIDES IN ALZHEIMERS-DISEASE
CORTICAL DISTRIBUTION OF GANGLIOSIDES IN ALZHEIMERS-DISEASE
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DOI：
10.1016/0197-0186(92)90058-y
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发表时间：
1992-04-01
影响因子：
4.2
通讯作者：
COSOVIC, C
中科院分区：
文献类型：
--
作者：
KRACUN, I;KALANJ, S;COSOVIC, C
在阿尔茨海默病中，所有神经节系列神经节苷脂（GM 1，GD 1a，GD 1b和GT 1b）被发现在颞叶和额叶皮质，Meynert基底核减少。此外，在阿尔茨海默病中，简单的神经节苷脂（GM 2，GM 3）在额叶和顶叶皮质中升高，可能与神经节苷脂的加速溶酶体降解和/或神经元死亡期间发生的星形胶质细胞增生相关。
In Alzheimer's disease, all ganglio-series gangliosides (GM1, GD1a, GD1b and GT1b) were found to be decreased in temporal and frontal cortex, and nucleus basalis of Meynert. In addition, in Alzheimer's disease simple gangliosides (GM2, GM3) were elevated in frontal and parietal cortex, possibly correlating to accelerated lysosomal degradation of gangliosides and/or astrogliosis occurring during neuronal death.