Predicting personal exposure of pregnant women to traffic-related air pollutants
Predicting personal exposure of pregnant women to traffic-related air pollutants
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DOI：
10.1016/j.scitotenv.2008.01.047
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发表时间：
2008-05-20
影响因子：
9.8
通讯作者：
Brauer, Michael
中科院分区：
文献类型：
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作者：
Nethery, Elizabeth;Teschke, Kay;Brauer, Michael
由于流行病学研究报告了环境空气污染与不良分娩结果之间的关联，因此必须了解孕妇接触污染的决定因素。我们测量（48小时，个人暴露）和建模（使用室外环境监测器和基于交通的土地利用回归模型）NO，NO2，细颗粒物质量和吸光度在62个非吸烟孕妇在加拿大温哥华在怀孕期间的1-3次（总N = 127）。我们开发了预测模型的个人测量使用建模的环境浓度和个人暴露的决定因素。个人样本的几何平均暴露量相对较低（GM（GSD）NO=37 ppb（2.0）; NO2 = 17 ppb（1.6）;“煤烟”，作为过滤器吸光度= 0.8 10（-5）m（-1）（1-5）; PM2.2 = 10 μ g m（-3）（1.6））。在家里有一个燃气灶（与电炉）与接触增加89%（NO），44%（NO2），20%（吸光度）和35%（细颗粒物）。从室外固定地点监测器的内插浓度与所有个人暴露，但NO2。土地利用回归模型估计室外空气污染与个人NO和NO2只。室外空气污染对个人样本的影响是一致的，有和没有调整其他个人的决定因素（如煤气炉）。这些研究结果提高了我们对孕妇暴露于空气污染物来源的理解，并支持使用室外浓度估计值作为流行病学研究中暴露的代理。(C)2008 Elsevier B. V.保留所有权利。
As epidemiological studies report associations between ambient air pollution and adverse birth outcomes, it is important to understand determinants of exposures among pregnant women. We measured (48-h, personal exposure) and modeled (using outdoor ambient monitors and a traffic-based land-use regression model) NO, NO2, fine particle mass and absorbance in 62 non-smoking pregnant women in Vancouver, Canada on 1-3 occasions during pregnancy (total N = 127). We developed predictive models for personal measurements using modeled ambient concentrations and individual determinants of exposure. Geometric mean exposures of personal samples were relatively low (GM (GSD) NO=37 ppb (2.0); NO2 = 17 ppb (1.6); 'soot', as filter absorbance = 0.8 10(-5) m(-1) (1-5); PM2.2 = 10 mu g m(-3) (1.6)). Having a gas stove (vs. electric stove) in the home was associated with exposure increases of 89% (NO), 44% (NO2),20% (absorbance) and 35% (fine PM). Interpolated concentrations from outdoor fixed-site monitors were associated with all personal exposures except NO2. Land-use regression model estimates of outdoor air pollution were associated with personal NO and NO2 only. The effects of outdoor air pollution on personal samples were consistent, with and without adjustment for other individual determinants (e.g. gas stove). These findings improve our understanding of sources of exposure to air pollutants among pregnant women and support the use of outdoor concentration estimates as proxies for exposure in epidemiologic studies. (C) 2008 Elsevier B.V. All rights reserved.