The stimulus-evoked population response in visual cortex of awake monkey is a propagating wave.
The stimulus-evoked population response in visual cortex of awake monkey is a propagating wave.
复制标题
DOI：
10.1038/ncomms4675
复制
发表时间：
2014-04-28
影响因子：
16.6
通讯作者：
Destexhe, Alain
中科院分区：
文献类型：
--
作者：
Muller, Lyle;Reynaud, Alexandre;Chavane, Frederic;Destexhe, Alain
传播波出现在许多可兴奋介质中，最近在从视网膜到新皮质的神经系统中发现了传播波。虽然传播波在麻醉状态下清晰存在，但它们是否也在清醒和有意识状态下出现仍不清楚。一种可能性是，由于变异性，这些波在试验平均数据中被系统地遗漏。在这里，我们提出了一种检测噪声多通道录音中传播波的方法。将该方法应用于单次试验电压敏感染料成像数据，我们表明，清醒猴子初级视觉皮层中刺激诱发的群体反应作为行波传播，在整个试验中具有一致的动态。网络模型表明，这种可靠性是浅层皮质层水平纤维网络的标志。具有相似特性的传播波在次级视觉皮层中独立发生，但与初级视觉皮层中的波保持精确的相位关系。这些结果表明，响应视觉刺激，在几个视觉区域系统地诱发传播波，为进一步的神经元相互作用产生一致的时空框架。 皮质神经元活动的传播波与各种认知过程有关，并且已在麻醉动物中观察到。在这里，作者证明了清醒猴子在视觉刺激期间存在传播波，并表明它们是由皮层中的水平纤维介导的。
Propagating waves occur in many excitable media and were recently found in neural systems from retina to neocortex. While propagating waves are clearly present under anaesthesia, whether they also appear during awake and conscious states remains unclear. One possibility is that these waves are systematically missed in trial-averaged data, due to variability. Here we present a method for detecting propagating waves in noisy multichannel recordings. Applying this method to single-trial voltage-sensitive dye imaging data, we show that the stimulus-evoked population response in primary visual cortex of the awake monkey propagates as a travelling wave, with consistent dynamics across trials. A network model suggests that this reliability is the hallmark of the horizontal fibre network of superficial cortical layers. Propagating waves with similar properties occur independently in secondary visual cortex, but maintain precise phase relations with the waves in primary visual cortex. These results show that, in response to a visual stimulus, propagating waves are systematically evoked in several visual areas, generating a consistent spatiotemporal frame for further neuronal interactions. Propagating waves of cortical neuronal activity are implicated in various cognitive processes and have been observed in anaesthetised animals. Here, the authors demonstrate the existence of propagating waves in awake monkeys during visual stimulation, and show that they are mediated by horizontal fibres in the cortex.
登录
查看更多内容
影响因子：
--
作者：
Chavane, F;Monier, C;Frégnac, Y
通讯作者：
Frégnac, Y
影响因子：
3.7
作者：
González-Burgos, G;Barrionuevo, G;Lewis, DA
通讯作者：
Lewis, DA
影响因子：
5.7
作者：
Alexander, David M.;Jurica, Peter;van Leeuwen, Cees
通讯作者：
van Leeuwen, Cees
影响因子：
--
作者：
Bullier, J
通讯作者：
Bullier, J
影响因子：
16.2
作者：
Ferezou, Isabelle;Haiss, Florent;Petersen, Carl C. H.
通讯作者：
Petersen, Carl C. H.