Surveillance study of candidemia in cancer patients in North China
Surveillance study of candidemia in cancer patients in North China
复制标题
华北地区癌症患者念珠菌血症监测研究
DOI：
10.3109/13693786.2012.727481
复制
发表时间：
2013-05-01
期刊：
影响因子：
2.9
通讯作者：
Liu, Zhe
中科院分区：
文献类型：
--
作者：
Li, Ding;Zhang, Wenfang;Liu, Zhe
对念珠菌血症危险因素的监测和分析对于减少癌症患者的治疗失败是必要的。通过了解念珠菌的地理分布。以及它们在癌症患者中的体外最小抗真菌抑制浓度，可以开发最佳治疗方案。回顾天津医科大学附属肿瘤医院2008 - 2010年癌症患者念珠菌血症数据，发现2006 - 2010年的发病率为0.34 - 0.53/1000例，粗死亡率为31.7%。白色念珠菌最常见（48.8%），其次为念珠菌。近平滑型（24.4%）; glabrata（9.8%）、C. tropicalis（9.8%）、C. lusitaniae（4.9%）和C. famata（2.3%）。所有种属均对唑类药物敏感，对阿替霉素B的MIC较低。手术是引起念珠菌血症的独立危险因素。白色念珠菌。此外，在所有癌症患者中，消化系统肿瘤患者最有可能发生念珠菌血症。此外，转移到远处器官的癌症患者明显更容易发生非C。白色念珠菌感染本研究提供了华北地区癌症患者念珠菌血症的流行病学资料，可能对这些患者的酵母菌感染有价值。
The surveillance and analysis of candidemia risk factors are necessary to reduce treatment failures in cancer patients. By understanding the geographic distribution of Candida spp. and their in vitro minimal antifungal inhibitory concentrations in cancer patients, optimal treatment protocols may be developed. On reviewing the candidemia data of cancer patients in Tianjin Medical University Cancer Institute and Hospital (TMUCIH), we found that the incidence rate was 0.34-0.53 cases per 1,000 admissions from 2008-2010, and the crude mortality was 31.7% during 2006-2010. Candida albicans was the most common species (48.8%), followed by C. parapsilosis (24.4%), C. glabrata (9.8%), C. tropicalis (9.8%), C. lusitaniae (4.9%), and C. famata (2.3%). All species were susceptible to azoles and showed low MICs to amphotericin B. Surgery was an independent risk factor in candidemia caused by C. albicans. Furthermore, among all cancer patients, those with digestive system neoplasms were most likely to develop candidemia. In addition, cancer patients with metastasis to distant organs were significantly more prone to non-C. albicans Candida infection. This study provided data on the epidemiology of candidemia in cancer patients in North China which may be of value in such individuals with yeast infections.