Functional imaging and the central control of the bladder
Functional imaging and the central control of the bladder
复制标题
DOI：
10.1002/cne.20753
复制
发表时间：
2005-12-05
影响因子：
2.5
通讯作者：
Fowler, CJ
中科院分区：
文献类型：
--
作者：
Bharat, R;Kavia, C;Fowler, CJ
膀胱的中枢控制是一个复杂的、多层次的过程。最近在脑功能成像方面的进展使得在人类身上进行这种控制的研究成为可能。这篇文章回顾了迄今为止发表的功能成像研究，并讨论了与中枢控制大小便有关的大脑区域。受累的脑区包括脑桥(脑桥排尿中心，PMC)、中脑导水管周围灰质(PAG)、丘脑、脑岛、前扣带回和前额叶皮质。PMC和PAG被认为是脊髓上控制大小便的关键。高级中枢，如脑岛、前扣带回和前额叶，可能参与了对膀胱感觉的控制和认知的调节，对于脑岛和前扣带回，可能参与了自主神经功能的调节。进一步的工作应该着眼于研究这些区域是如何相互作用来实现排尿控制的。
The central control of the bladder is a complex, multilevel process. Recent advances in functional brain imaging have allowed research into this control in humans. This article reviews the functional imaging studies published to date and discusses the regions of the brain that have been implicated in the central control of continence. Brain regions that have been implicated include the pons (pontine micturition center, PMC), periaqueductal gray (PAG), thalamus, insula, anterior cingulate gyrus, and prefrontal cortices. The PMC and the PAG are thought to be key in the supraspinal control of continence and micturition. Higher centers such as the insula, anterior cingulate gyrus, and prefrontal regions are probably involved in the modulation of this control and cognition of bladder sensations, and in the case of the insula and anterior cingulate, modulation of autonomic function. Further work should aim to examine how the regions interact to achieve urinary continence.