The Role of Cardiolipin in Cardiovascular Health.
The Role of Cardiolipin in Cardiovascular Health.
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DOI：
10.1155/2015/891707
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发表时间：
2015
影响因子：
--
通讯作者：
Greenberg ML
中科院分区：
文献类型：
--
作者：
Shen Z;Ye C;McCain K;Greenberg ML
心磷脂（CL）是线粒体膜的标志性磷脂，对线粒体功能和线粒体外的细胞过程都至关重要。危及生命的遗传疾病巴斯综合征（BTHS）强调了CL在心血管健康中的重要性，其临床表现为心肌病、骨骼肌病、中性粒细胞减少症和生长迟缓。BTHS是由编码tafazzin的基因突变引起的，tafazzin是进行第二步CL重塑的转酰基酶。除了BTHS， CL还与其他心血管疾病（cvd）有关，包括心肌病、动脉粥样硬化、心肌缺血再灌注损伤、心力衰竭和丹吉尔病。CL与CVD之间的联系可能是由CL在心脏保护途径中的生理作用来解释的，包括线粒体生物能量学、自噬/线粒体自噬和有丝分裂原活化蛋白激酶（MAPK）途径。本文就CL在CVD发病中的作用以及CL功能与心血管健康之间的分子机制进行综述。
Cardiolipin (CL), the signature phospholipid of mitochondrial membranes, is crucial for both mitochondrial function and cellular processes outside of the mitochondria. The importance of CL in cardiovascular health is underscored by the life-threatening genetic disorder Barth syndrome (BTHS), which manifests clinically as cardiomyopathy, skeletal myopathy, neutropenia, and growth retardation. BTHS is caused by mutations in the gene encoding tafazzin, the transacylase that carries out the second CL remodeling step. In addition to BTHS, CL is linked to other cardiovascular diseases (CVDs), including cardiomyopathy, atherosclerosis, myocardial ischemia-reperfusion injury, heart failure, and Tangier disease. The link between CL and CVD may possibly be explained by the physiological roles of CL in pathways that are cardioprotective, including mitochondrial bioenergetics, autophagy/mitophagy, and mitogen activated protein kinase (MAPK) pathways. In this review, we focus on the role of CL in the pathogenesis of CVD as well as the molecular mechanisms that may link CL functions to cardiovascular health.