The critical role of STIM1-dependent Ca2+ signalling during T-cell development and activation.
The critical role of STIM1-dependent Ca2+ signalling during T-cell development and activation.
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DOI：
10.1016/j.biocel.2013.07.014
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发表时间：
2013-11
影响因子：
4
通讯作者：
Soboloff, Jonathan
中科院分区：
文献类型：
--
作者：
Samakai, Elsie;Hooper, Robert;Soboloff, Jonathan
T淋巴细胞是适应性免疫的关键细胞效应器，能够识别几乎无限数量的抗原肽并发起免疫反应。Ca2+信号对T细胞的发育和激活至关重要，基质相互作用分子1 （STIM1）已被确定为T细胞内Ca2+水平的关键调节剂。尽管STIM1在T细胞活化中的作用已被广泛研究，但STIM1在T细胞发育中的作用仍存在一些争议。事实上，STIM1表达和功能的缺陷不仅会导致与自身免疫发展相关的发育缺陷，还会干扰T细胞的激活，导致严重的联合免疫缺陷，这表明STIM1在T细胞生理和病理生理中具有多方面的作用。
T lymphocytes are key cellular effectors of adaptive immunity able to recognize a virtually limitless number of antigenic peptides and mount an immune response. Ca2+ signals are crucial to the development and activation of T cells and Stromal Interaction Molecule 1 (STIM1) has been identified as a critical modulator of intracellular Ca2+ levels in T cells. Although the role of STIM1 in T cell activation has been extensively investigated, the role of STIM1 in T cell development has been somewhat controversial. Indeed, deficiencies in STIM1 expression and function lead to both developmental defects associated with the development of autoimmunity yet also interfere with T cell activation leading to severe combined immunodeficiency signifying a multifaceted role of STIM1 in T cell physiology and pathophysiology.
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影响因子：
64.8
作者：
Daniels, Mark A.;Teixeiro, Emma;Palmer, Ed
通讯作者：
Palmer, Ed
影响因子：
4.8
作者：
DeHaven, Wayne I.;Smyth, Jeremy T.;Putney, James W., Jr.
通讯作者：
Putney, James W., Jr.
影响因子：
11.4
作者：
Quintana, Ariel;Pasche, Mathias;Hoth, Markus
通讯作者：
Hoth, Markus
DOI：
10.1007/978-1-4614-1680-7_13
发表时间：
2012-01-01
期刊：
SELF AND NONSELF
影响因子：
--
作者：
Danilova, Nadia
通讯作者：
Danilova, Nadia
影响因子：
4.5
作者：
Feske, Stefan
通讯作者：
Feske, Stefan