Recurrent otitis media and tonsillitis:: common disease predisposition
Recurrent otitis media and tonsillitis:: common disease predisposition
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DOI：
10.1016/j.ijporl.2006.04.004
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发表时间：
2006-09-01
影响因子：
1.5
通讯作者：
Magnus, Per
中科院分区：
文献类型：
--
作者：
Kvestad, Ellen;Kvaerner, Kari Jorunn;Magnus, Per
目的：评估遗传和环境效应在复发性中耳炎和复发性扁桃体炎之间的相对贡献。方法：对1967-1979年出生的9479对挪威双胞胎进行自我报告问卷调查。复发性中耳炎和复发性扁桃体炎是主要的预后指标。结果：复发性扁桃体炎终生患病率为11.7%(95%CI：11.0~12.3)，复发性中耳炎终生患病率为11.2%(95%CI 10.5~11.9)。在配偶和女性中，同卵双生子和同卵双生子的四色相关性都大于异卵双胞胎。中耳炎和扁桃体炎的加性遗传效应和个体环境效应以及扁桃体炎的非加性遗传效应的模型得到了最好的拟合。没有证据表明遗传来源或遗传效应的大小存在性别差异。影响中耳炎和扁桃体炎易感性差异的遗传因素有很大的重叠。结论：共同的遗传因素在很大程度上导致了复发性中耳炎和复发性扁桃体炎的共病。(C)2006爱思唯尔爱尔兰有限公司。保留所有权利。
Objective: To estimate the relative contribution of genetic and environmental effects to the association between recurrent otitis media and recurrent tonsillitis.Methods: Self-report questionnaire data from a population-based cohort of 9479 Norwegian twins born from 1967 to 1979. Recurrent otitis media and recurrent tonsillitis were main outcome measures. Structural equation modelling was used to fit alternative biometric models to the twin data and to estimate the relative contribution of genetic and environmental effects to the association between otitis media and tonsillitis.Results: The lifetime prevalence was 11.7% (95% CI: 11.0-12.3) for recurrent tonsillitis and 11.2% (95% CI 10.5-11.9) for recurrent otitis media. Tetrachoric correlations were greater in monozygotic than in dizygotic twins in both mates and females. A model specifying additive genetic effects and individual environmental effects for otitis media and tonsillitis and non-additive genetic effects for tonsillitis yielded the best fit. There was no evidence for sex differences in the genetic source or magnitude of the genetic effects. There was a substantial overlap in genetic factors influencing variation in Liability to otitis media and tonsillitis.Conclusion: Common genetic factors contribute substantially to comorbidity between recurrent otitis media and recurrent tonsillitis. (C) 2006 Elsevier Ireland Ltd. All rights reserved.