Association of Meat Intake and Meat-Derived Mutagen Exposure with the Risk of Colorectal Polyps by Histologic Type
Association of Meat Intake and Meat-Derived Mutagen Exposure with the Risk of Colorectal Polyps by Histologic Type
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DOI：
10.1158/1940-6207.capr-11-0191
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发表时间：
2011-10-01
影响因子：
3.3
通讯作者：
Zheng, Wei
中科院分区：
文献类型：
--
作者：
Fu, Zhenming;Shrubsole, Martha J.;Zheng, Wei
肉类摄入量和肉类诱变剂与结直肠肿瘤风险的关系仍不清楚。我们在一项基于结肠镜检查的大型病例对照研究中评估了这一假设。该研究包括 2,543 名息肉患者[（1,881 名腺瘤患者和 622 名增生性息肉 (HPP)] 和 3,764 名无息肉对照者。调查通过烹饪方法和熟度水平以及其他可疑或已知的结直肠肿瘤风险因素获得了有关肉类摄入量的信息。在调整潜在混杂因素后，使用无条件逻辑回归得出 OR。红肉和加工肉类的高摄入量（P（趋势）< 0.05），特别是使用高温烹饪方法烹制的红肉（P（趋势）
The association of meat intake and meat-derived mutagens with colorectal tumor risk remains unclear. We evaluated this hypothesis in a large colonoscopy-based case-control study. Included in the study were 2,543 patients with polyp [(1,881 with adenomas and 622 with hyperplastic polyp (HPP)] and 3,764 polyp-free controls. Surveys obtained information about meat intake by cooking methods and doneness levels plus other suspected or known risk factors for colorectal tumors. Unconditional logistic regression was used to derive ORs after adjusting for potential confounders. High intake of red meat and processed meat (P(trend) < 0.05), particularly red meat cooked using high-temperature cooking methods (P(trend)