Multicomponent microspheres with spatiotemporal drug release for post-surgical liver cancer treatment and liver regeneration
Multicomponent microspheres with spatiotemporal drug release for post-surgical liver cancer treatment and liver regeneration
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DOI：
10.1016/j.cej.2022.140585
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发表时间：
2022-12
影响因子：
15.1
通讯作者：
Jinwei Zhong;Qingfei Zhang;Gaizhen Kuang;Jinglin Xia;Luoran Shang
中科院分区：
文献类型：
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作者：
Jinwei Zhong;Qingfei Zhang;Gaizhen Kuang;Jinglin Xia;Luoran Shang
肝切除术后肿瘤复发是当前肝癌治疗面临的严峻挑战。在这里，我们提出了新的多组分微球（MCMs）与共封装和时空药物释放能力，手术后肝癌治疗和肝再生。通过分步微流控平台制造MCM，并且MCM由海藻酸钠（ALG）壳和明胶甲基丙烯酸酯（GelMA）核组成。得益于“粒子中粒子”的结构，MCMs提供了将阿霉素（DOX）和肝再生增强因子（ALR）分别装载到壳和核中的可能性。此外，MCMs使DOX的快速释放和ALR的更持续释放成为可能。因此，双载药MCMs具有显著的术后肿瘤杀伤和促进肝再生的作用。我们预计，目前的MCMs有显着的潜力，作为多功能的药物输送系统，手术后的癌症治疗。
Tumor recurrence after hepatic resection is a severe challenge of current liver cancer treatment. Here we present novel multicomponent microspheres (MCMs) with co-encapsulation and spatiotemporal drug release capabilities for post-surgical liver cancer treatment and liver regeneration. The MCMs were fabricated via a stepwise microfluidic platform and were composed of a sodium alginate (ALG) shell and gelatin methacrylate (GelMA) cores. Benefitting from the “particle-in-particle” structure, the MCMs provided the possibility of loading doxorubicin (DOX) and augmenter of liver regeneration (ALR) into the shell and the cores, respectively. Besides, the MCMs enabled rapid release of DOX and more sustained release of ALR. Therefore, the dual-drug-loaded MCMs exhibited prominent effects of postsurgical tumor killing and promoting liver regeneration. We anticipate that the present MCMs have remarkable potentials as versatile drug delivery systems for post-surgical cancer therapy.