Role of molecular diffusion in conventional and high frequency ventilation.
Role of molecular diffusion in conventional and high frequency ventilation.
复制标题
分子扩散在常规和高频通气中的作用。
DOI：
10.1164/ajrccm/142.4.802
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Zhang,S
中科院分区：
文献类型：
--
作者：
Klocke,RA;Saltzman,AR;Grant,BJ;Aquilina,AT;Zhang,S
通过观察动脉血中六种难溶性惰性气体的渗透情况，研究了传统机械通气 (CMV) 和高频通气 (HFV) 期间分子扩散对气体混合的影响。麻醉犬用 CMV 或 HFV 通气。在吸入气体成分发生阶跃变化后，通过气相色谱法测定氢气、氦气、甲烷、乙烷、异丁烷和六氟化硫的动脉浓度的增加。相对气体扩散量涵盖了几乎一个数量级的范围。在控制和冲洗阶段，吸入气体中存在丙烷，用作计算血液示踪剂浓度的内部参考。在 CMV 和 HFV 期间，所有六种惰性气体的冲洗均遵循单一指数时间过程。每种气体的洗入率随着分子量（MW）的增加而降低。对于两种类型的通气，速率常数与相对扩散度 (MW-0.5) 的关系与零显着不同。
The influence of molecular diffusion on gas-mixing during conventional mechanical ventilation (CMV) and high frequency ventilation (HFV) was studied by observing the wash-In of six poorly soluble, Inert gases In arterial blood. Anesthetized dogs were ventilated either with CMV or HFV. Following a step change In Inspired gas composition, the Increase In arterial concentrations of hydrogen, helium, methane, ethane, Isobutane, and sulfur hexafluoride was determined by gas chromatography. The relative gas dlffuslvltles encompassed a range of almost one order of magnitude. Propane, present In Inspired gas during both the control and wash-In phases, served as an internal reference for calculation of blood tracer concentrations. The wash-In of all six Inert gases followed a single exponential time course during both CMV and HFV. The rate of wash-In of each gas decreased with Increasing molecular weight (MW). The relationship of rate constants to a measure of relative dlffuslvlty (MW-0.5) was significantly different than zero for both types of ventilation.