Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models.
Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models.
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DOI：
10.3109/03602532.2010.512294
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发表时间：
2011-02
影响因子：
5.9
通讯作者：
Yu AM
中科院分区：
文献类型：
--
作者：
Jiang XL;Gonzalez FJ;Yu AM
确定特定酶、转运蛋白或外源性受体在药物代谢和药代动力学中的体内重要性可能会受到基因的多样性和复杂性、表达水平以及所涉及的各种成分之间的相互作用的阻碍。基因敲除（功能丧失）和转基因（功能获得）小鼠模型的开发为更好地了解全身系统中的基因功能打开了大门。人们对开发人源化小鼠以克服药物代谢和处置方面的物种差异也越来越感兴趣。因此，本综述旨在总结和讨论药物代谢酶、转运蛋白和核受体转基因小鼠模型的一些成功实例。这些转基因小鼠模型已被证明是了解药物代谢酶、转运蛋白和外源性受体在药物代谢和转运中的体内功能，以及预测人类潜在的药物相互作用和毒性的宝贵模型。然而，对从相关基因表达显着改变的此类转基因小鼠模型获得的数据的解释仍然存在担忧。
Determining the in vivo significance of a specific enzyme, transporter or xenobiotic receptor in drug metabolism and pharmacokinetics may be hampered by gene multiplicity and complexity, levels of expression and interaction between various components involved. The development of knockout (loss-of-function) and transgenic (gain-of-function) mouse models opens the door to the improved understanding of gene function in a whole body system. There is also growing interest in the development of humanized mice to overcome species difference in drug metabolism and disposition. This review, therefore, aims to summarize and discuss some successful examples of drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models. These genetically modified mouse models have proven as invaluable models for understanding in vivo function of drug-metabolizing enzymes, transporters and xenobiotic receptors in drug metabolism and transport, as well as predicting potential drug-drug interaction and toxicity in humans. Nevertheless, concerns remain about interpretation of data obtained from such genetically modified mouse models in which the expression of related genes is altered significantly.
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影响因子：
11.2
作者：
Cheung, C;Akiyama, TE;Gonzalez, FJ
通讯作者：
Gonzalez, FJ
影响因子：
3.9
作者：
Cheung, C;Yu, AM;Gonzalez, FJ
通讯作者：
Gonzalez, FJ
DOI：
10.1124/jpet.107.121780
发表时间：
2007-07-01
影响因子：
3.5
作者：
Finn, Robert D.;McLaren, Aileen W.;Wolf, C. Roland
通讯作者：
Wolf, C. Roland
影响因子：
3.9
作者：
Cai, Hongliang;Nguyen, Nghia;Stevens, Jeffrey C.
通讯作者：
Stevens, Jeffrey C.
DOI：
10.1073/pnas.0913290107
发表时间：
2010-03-16
影响因子：
11.1
作者：
Fujiwara, Ryoichi;Nguyen, Nghia;Tukey, Robert H.
通讯作者：
Tukey, Robert H.