Reduction of amides to amines via catalytic hydrosilylation by a rhodium complex
Reduction of amides to amines via catalytic hydrosilylation by a rhodium complex
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DOI：
10.1016/s0040-4039(97)10804-8
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发表时间：
1998-02-26
影响因子：
1.8
通讯作者：
Ito, Y
中科院分区：
文献类型：
--
作者：
Kuwano, R;Takahashi, M;Ito, Y
0.1 mol% 的 RhH(CO)(PPh3)3 在室温下促进了 2 摩尔当量二苯基硅烷对多种叔酰胺的还原，以高产率提供了相应的叔胺。通过化学选择性还原具有酯基和环氧基等官能团的酰胺，证明了合成实用性，而传统的 LiAlH4 和 BH3 还原不能耐受这些官能团。 (C) 1998 Elsevier Science Ltd. 保留所有权利。
Reduction of a wide range of tertiary amides with 2 molar equivalents of diphenylsilane was promoted by 0.1 mol% of RhH(CO)(PPh3)3 at room temperature, affording the corresponding tertiary amines in high yields. The synthetic utility is demonstrated by chemoselective reductions of amides having functional groups such as ester and epoxy groups which are not tolerated by the conventional reductions with LiAlH4 and BH3. (C) 1998 Elsevier Science Ltd. All rights reserved.