A retrospective study of 60 cases of eccentrocytosis in the dog
A retrospective study of 60 cases of eccentrocytosis in the dog
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DOI：
10.1111/j.1939-165x.2005.tb00045.x
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发表时间：
2005-09-01
影响因子：
1.2
通讯作者：
Lubas, G
中科院分区：
文献类型：
--
作者：
Caldin, M;Carli, E;Lubas, G
背景：偏心红细胞是出现在外周血涂片中的红细胞，其血红蛋白转移到细胞的一侧。这种局限于红细胞膜和细胞骨架的异常是由氧化损伤引起的。偏心细胞在狗中很少报告，与洋葱和大蒜的摄入和氧化剂药物的管理有关。目的：本研究的目的是描述发生和严重程度的偏心细胞症的狗和疾病或障碍与偏心细胞。研究方法：对2.5年期间收治的所有犬患者的详细病史、体格检查、CBC、生化和凝血特征以及尿分析结果进行了评价。当观察到偏心细胞时，将其分级为1+（很少）至4+（很多）。并与贫血和网织红细胞增多症的严重程度进行比较。结果如下：4251只犬中有60只（1.4%）在血涂片中发现了偏心细胞，其中40只（66.6%）与轻度至中度贫血有关。16例出现偏心细胞增多（26.6%）给药犬，11只（18.3%）假定洋葱和大蒜摄入量，8维生素K拮抗剂中毒占13.3%，（11.6%）酮症酸中毒性糖尿病，5 T细胞淋巴瘤8例（8.3%），严重感染4例（6.6%），代偿性糖尿病1例（1.6%），其他8例（13.3%）。某些狗品种，如白色，拳击手，英国二传手，和年轻的狗似乎是过度代表。结论：我们描述，第一次，偏心细胞和糖尿病，T细胞淋巴瘤和维生素K拮抗剂中毒的狗之间的关联。不应低估偏心细胞的重要性，因为它们可能是氧化过程的信号。
Background: Eccentrocytes are RBCs that appear in a peripheral blood smear to have their hemoglobin shifted to one side of the cell. This abnormality, which is confined to the RBC membrane and cytoskeleton, is induced by oxidative damage. Eccentrocytes have been reported rarely in dogs and are associated with onion and garlic ingestion and the administration of oxidant drugs. Objective: The purpose of this study was to describe the occurrence and severity of eccentrocytosis in dogs and the diseases or disorders associated with eccentrocytes. Methods: Detailed history, and results of physical examination, CBC, biochemical and coagulation profiles, and urinalysis from all canine patients admitted during a 2.5-year period were evaluated. Eccentrocytes, when observed, were graded 1+ (few) to 4+ (many). The severity of eccentrocytosis was compared with that of anemia and reticulocytosis. Results: Eccentrocytes were found in blood smears from 60 of 4251 dogs (1.4%) and were associated with mild to moderate anemia in 40 (66.6%) of the cases. Eccentrocytosis was found in 16 (26.6%) dogs with drug administration, 11 (18.3%) with presumptive onion and garlic ingestion, 8 (13.3%) with vitamin K antagonist intoxication, 7 (11.6%) with ketoacidotic diabetes, 5 (8.3%) with T-cell lymphoma, 4 (6.6%) with severe infections, 1 (1.6%) with compensated diabetes mellitus, and 8 (13.3%) with other conditions. Certain dog breeds, such as Whippet, Boxer, and English Setter, and young dogs seemed to be overrepresented. Conclusions: We describe, for the first time, associations between eccentrocytes and diabetes mellitus, T-cell lymphoma and vitamin K antagonist intoxication in dogs. The significance of eccentrocytes should not be underestimated, because they can be a signal of an oxidative process.