Oxidative stress caused by lead (Pb) induces iron deficiency in Drosophila melanogaster
Oxidative stress caused by lead (Pb) induces iron deficiency in Drosophila melanogaster
复制标题
铅（Pb）引起的氧化应激导致果蝇缺铁
DOI：
10.1016/j.chemosphere.2019.125428
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发表时间：
2020-03-01
期刊：
影响因子：
8.8
通讯作者：
Xiao, Guiran
中科院分区：
文献类型：
--
作者：
Liu, Zhi-Hua;Shang, Jin;Xiao, Guiran
有毒元素暴露会扰乱生物体中必需元素的动态平衡，但其机制仍不清楚。在本研究中，我们证明了果蝇暴露于铅(铅是一种普遍存在的对人类健康的威胁)中表现出各种健康缺陷，包括发育迟缓、存活率下降、行动能力受损和产卵减少。这些表型可以通过干预饮食铁水平或改变铁代谢相关基因的表达来显著调节。进一步的研究表明，铅暴露会导致全身性铁缺乏。值得注意的是，ROS的清除通过恢复中肠铁代谢基因的表达，显著增加了铁的吸收，从而减轻了铅的毒性。这项研究强调了ROS在铅诱导的铁代谢紊乱中的作用，为理解铅中毒的机制提供了独特的见解，并提出了通过补铁治疗或清除ROS来减轻铅中毒的理想方法。(C)2019爱思唯尔有限公司。保留所有权利。
Toxic elements exposure disturbs the homeostasis of essential elements in organisms, but the mechanism remains elusive. In this study, we demonstrated that Drosophila melanogaster exposed to Lead (Pb, a pervasive environmental threat to human health) exhibited various health defects, including retarded development, decreased survival rate, impaired mobility and reduced egg production. These phenotypes could be significantly modulated by either intervention of dietary iron levels or altering expression of genes involved in iron metabolism. Further study revealed that Pb exposure leads to systemic iron deficiency. Strikingly, reactive oxygen species (ROS) clearance significantly increased iron uptake by restoring the expression of iron metabolism genes in the midgut and subsequently attenuated Pb toxicity. This study highlights the role of ROS in Pb induced iron dyshomeostasis and provides unique insights into understanding the mechanism of Pb toxicity and suggests ideal ways to attenuate Pb toxicity by iron supplementation therapy or ROS clearance. (C) 2019 Elsevier Ltd. All rights reserved.