[Development of coronary atherosclerosis in the elderly].
[Development of coronary atherosclerosis in the elderly].
复制标题
老年人冠状动脉粥样硬化的进展[J].
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
K. Kuramoto
中科院分区：
文献类型：
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作者：
S. Ueda;K. Kuramoto
在东京都立老年病医院，对3569例年龄在60 ~ 99岁之间的连续尸检病例进行了研究，探讨了老龄化、高血压和血浆胆固醇在冠状动脉粥样硬化发展中的作用。冠状动脉粥样硬化的患病率随年龄增长而增加。收缩期和舒张期高血压均与冠状动脉粥样硬化的患病率有关。高血浆胆固醇（230 mg/dl）与冠状动脉粥样硬化患病率增加有关。这种效应在高血压组中观察到，但在血压正常组中没有观察到。为了确定高血压对血管疾病的影响，从自发性高血压大鼠（SHR）的内皮细胞获得和表征的细胞反应。与血压正常的Wistar-Kyoto大鼠（WKY）相比，SHR对A23187的反应性细胞内Ca ~（2+）水平显著升高。因此，衰老、高血压和高血浆胆固醇是老年人冠状动脉粥样硬化的危险因素。
The role of aging, hypertension and plasma cholesterol in the development of coronary atherosclerosis was examined in 3569 consecutive autopsy cases, aged 60 to 99 years, at the Tokyo Metropolitan Geriatric Hospital. The prevalence of coronary atherosclerosis increased with aging. Both systolic and diastolic hypertension were related to the prevalence of coronary atherosclerosis. High plasma cholesterol (230 mg/dl) was related to increased prevalence of coronary atherosclerosis. This effect was observed in a hypertensive group, but not in a normotensive group. To define the effect of hypertension on vascular diseases, endothelial cells from spontaneously hypertensive rats (SHR) were obtained and characterized in terms of cellular response. Cellular Ca2+ level in response to A23187 was significantly enhanced in SHR compared to normotensive Wistar-Kyoto rats (WKY). Thus, aging, hypertension and high plasma cholesterol are risk factors for coronary artery atherosclerosis in the elderly.