The calcium signaling toolkit of the Apicomplexan parasites Toxoplasma gondii and Plasmodium spp.
The calcium signaling toolkit of the Apicomplexan parasites Toxoplasma gondii and Plasmodium spp.
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Apicomplexan寄生虫的钙信号传导工具包弓形虫和疟原虫属。
DOI：
10.1016/j.ceca.2014.12.010
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发表时间：
2015-03
期刊：
影响因子：
4
通讯作者：
Moreno SN
中科院分区：
文献类型：
--
作者：
Lourido S;Moreno SN
Apicomplexan parasites have complex life cycles, frequently split between different hosts and reliant on rapid responses as the parasites react to changing environmental conditions. Calcium ion (Ca2+) signaling is consequently essential for the cellular and developmental changes that support apicomplexan parasitism. Apicomplexan genomes reveal a rich repertoire of genes involved in calcium signaling, although many of the genes responsible for observed physiological changes remain unknown. There is evidence, for example, for the presence of a nifedipine-sensitive calcium entry mechanism in Toxoplasma, but the molecular components involved in Ca2+ entry in both Toxoplasma and Plasmodium, have not been identified. The major calcium stores are the endoplasmic reticulum (ER), the acidocalcisomes, and the plant-like vacuole in Toxoplasma, or the food vacuole in Plasmodium spp. Pharmacological evidence suggests that Ca2+ release from intracellular stores may be mediated by inositol 1,4,5-trisphosphate (IP3) or cyclic ADP ribose (cADPR) although there is no molecular evidence for the presence of receptors for these second messengers in the parasites. Several Ca2+-ATPases are present in apicomplexans and a putative mitochondrial Ca2+/H+ exchanger has been identified. Apicomplexan genomes contain numerous genes encoding Ca2+-binding proteins, with the notable expansion of calcium-dependent protein kinases (CDPKs), whose study has revealed novel roles in gliding motility, microneme secretion, host cell invasion and egress, and parasite differentiation. Microneme secretion has also been shown to depend on the C2 domain containing protein DOC2 in both Plasmodium spp. and Toxoplasma, providing further evidence for the complex transduction of Ca2+ signals in these organisms. The characterization of these pathways could lead to the discovery of novel drug targets and to a better understanding of the role of Ca2+ in these parasites.
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影响因子：
4
作者：
Besteiro, Sebastien;Tonn, Daniela;Mottram, Jeremy C.
通讯作者：
Mottram, Jeremy C.
DOI：
10.1083/jcb.200309097
发表时间：
2004-06-07
期刊：
The Journal of cell biology
影响因子：
--
作者：
Arrizabalaga G;Ruiz F;Moreno S;Boothroyd JC
通讯作者：
Boothroyd JC
DOI：
10.1126/science.1214977
发表时间：
2012-05-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bick AG;Calvo SE;Mootha VK
通讯作者：
Mootha VK
影响因子：
3.4
作者：
Carey, Allison F.;Singer, Mirko;Amino, Rogerio
通讯作者：
Amino, Rogerio
影响因子：
3.7
作者：
Egarter, Saskia;Andenmatten, Nicole;Meissner, Markus
通讯作者：
Meissner, Markus