Outbreak of Electronic-Cigarette–Associated Acute Lipoid Pneumonia — North Carolina, July–August 2019
Outbreak of Electronic-Cigarette–Associated Acute Lipoid Pneumonia — North Carolina, July–August 2019
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电子烟相关急性类脂性肺炎爆发 — 北卡罗来纳州，2019 年 7 月至 8 月
DOI：
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Daniel Fox
中科院分区：
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作者：
Kevin R Davidson;A. Brancato;Peter Heetderks;W. Mansour;E. Matheis;Myra Nario;Shri V. Rajagopalan;Bailey Underhill;J. Wininger;Daniel Fox
2019年9月6日，本报告作为MMWR早期版本发布在MMWR网站（https：//www.cdc.gov/mmwr）上。电子香烟（e-cigarettes）通过加热通常含有尼古丁，香料和其他化学物质的液体来产生气溶胶，这种行为通常被称为“vaping”。“电子烟也可以用来运送大麻和其他毒品。最近几个月，来自25个州的报告了200多例可能与vaping相关的急性肺损伤病例。在2019年7月和8月期间，在北卡罗来纳州的两家医院发现了5名患者，他们患有可能与电子烟使用相关的急性肺损伤。患者为18-35岁的成年人，均出现数天呼吸困难、恶心、呕吐、腹部不适和发热恶化。所有患者均表现为呼吸急促，检查时呼吸功增加，低氧血症（脉搏血氧饱和度<90%，室内空气），胸部X线检查时双侧肺浸润。所有五名患者都有最近在电子烟中使用大麻油或浓缩物的历史。所有使用的产品都是电子烟笔/电子烟，它们具有可再填充的腔室或可互换的四氢大麻酚（THC）蒸汽浓缩物或油，这些都是在街上购买的。其中三名患者还使用含尼古丁的电子烟，两名患者吸食大麻或传统香烟，尽管没有使用其他非法药物。所有5名患者均因低氧性呼吸衰竭住院; 3名患者因急性呼吸窘迫综合征需要重症监护，其中1名患者需要插管和机械通气。所有患者均存活。
On September 6, 2019, this report was posted as an MMWR Early Release on the MMWR website (https://www.cdc.gov/mmwr). Electronic cigarettes (e-cigarettes) produce an aerosol by heating a liquid that usually contains nicotine, flavorings, and other chemicals that users inhale, a behavior commonly referred to as "vaping." E-cigarettes can also be used to deliver marijuana and other drugs. In recent months, more than 200 possible cases of acute lung injury potentially associated with vaping were reported from 25 states (1). During July and August 2019, five patients were identified at two hospitals in North Carolina with acute lung injury potentially associated with e-cigarette use. Patients were adults aged 18-35 years and all experienced several days of worsening dyspnea, nausea, vomiting, abdominal discomfort and fever. All patients demonstrated tachypnea with increased work of breathing on examination, hypoxemia (pulse oximetry <90% on room air), and bilateral lung infiltrates on chest x-ray. All five patients shared a history of recent use of marijuana oils or concentrates in e-cigarettes. All of the products used were electronic vaping pens/e-cigarettes that had refillable chambers or interchangeable cartridges with tetrahydrocannabinol (THC) vaping concentrates or oils, which were all purchased on the street. Three of the patients also used nicotine-containing e-cigarettes, and two of the patients smoked marijuana or conventional cigarettes, although none used other illicit drugs. All five patients were hospitalized for hypoxemic respiratory failure; three required intensive care for acute respiratory distress syndrome, one of whom required intubation and mechanical ventilation. All of the patients survived.