Alcohol consumption, type of alcoholic beverage and risk of colorectal cancer at specific subsites
Alcohol consumption, type of alcoholic beverage and risk of colorectal cancer at specific subsites
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DOI：
10.1002/ijc.23774
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发表时间：
2008-11-15
影响因子：
6.4
通讯作者：
Weijenberg, Matty P.
中科院分区：
文献类型：
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作者：
Bongaerts, Brenda W. C.;van den Brandt, Piet A.;Weijenberg, Matty P.
在荷兰关于饮食和癌症的队列研究中，我们根据解剖学亚位点调查了总酒精摄入量，特定酒精饮料摄入量和结直肠癌（CRC）风险之间的关系。使用考克斯比例风险模型估计风险比（HR）和95%置信区间（CI）。对2，323例CRC病例进行了分析，这些病例在随访13.3年后可用。与戒酒相比，饮酒≥ 30.0 g/天（相当于3杯酒精饮料）与CRC风险呈正相关（HR：1.32，95% CI：1.00-4.65）。仅限于报告基线前5年饮酒量与基线相比相等的受试者的分析显示，每天饮酒总量>= 30.0 g的消费者的风险估计值也升高（HR：1.53，95% CI：1.16-2.01）。提示亚单位特异性效应，癌症风险似乎从近端结肠到直肠增加;近端结肠癌HR：1.29，95% CI：0.85-1.96，远端结肠癌HR：1.41，95% CI- 0.94-2.11，直肠乙状结肠癌HR：2.07，95% CI：1.0-3-4.18，HR：1.69，直肠癌的95% CI：1.08-2.64。与特定饮料的非饮酒者相比，并在调整总酒精摄入量后，未观察到酒精饮料消费与CRC风险之间的关联。没有证据表明酒精和酒精饮料对性别的影响。总之，我们的数据显示酒精消费与CRC风险之间存在正相关，这似乎主要是由酒精饮料的酒精含量而不是其他成分解释的。此外，癌症风险可能会因解剖部位而异。(c)2008 Wiley-Liss，Inc.
Within the Netherlands Cohort Study on diet and cancer, we investigated associations between total alcohol consumption, specific alcoholic beverage consumption and risk of colorectal cancer (CRC) according to anatomical subsite. Hazard Ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models. Analyses were performed on 2,323 CRC cases, available after 13.3 years of follow-up. Compared to abstaining, alcohol consumption of >= 30.0 g/day (similar to 3 alcoholic drinks) was positively associated with the risk of CRC (HR: 1.32, 95% CI: 1.00-4.65). Analyses restricted to subjects who reported to have consumed equal amounts of alcohol 5 years before baseline compared to baseline, showed elevated risk estimates for consumers of >= 30.0 g of total alcohol per day as well (HR: 1.53, 95% CI: 1.16-2.01). Suggestive of a subsite-specific effect, cancer risk seemed to increase from proximal colon through rectum; HR: 1.29, 95% CI: 0.85-1.96 for proximal colon cancer, HR: 1.41, 95% CI- 0.94-2.11 for distal colon cancer, HR: 2.07, 95% Cl: 1.0-3-4.18 for rectosigmoid cancer and HR: 1.69, 95% Cl: 1.08-2.64 for rectal cancer. No associations were observed between consumption of alcoholic beverages and CRC risk when compared with the nondrinkers of the specific beverage and after adjustment for total alcohol intake. No evidence was found for sex-specific effects of alcohol and alcoholic beverages. In conclusion, our data showed a positive association between alcohol consumption and risk of CRC, which seemed to be mainly explained by the alcoholic content of alcoholic beverages, rather than other constituents. Also, cancer risk may vary according to anatomical subsite. (c) 2008 Wiley-Liss, Inc.