Opiates and Plasticity in the Ventral Tegmental Area.
Opiates and Plasticity in the Ventral Tegmental Area.
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腹侧对接区域的鸦片和可塑性。
DOI：
10.1021/acschemneuro.7b00281
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发表时间：
2017-09-20
影响因子：
5
通讯作者：
Nugent FS
中科院分区：
文献类型：
--
作者：
Langlois LD;Nugent FS
阿片类药物是最有效的止痛药之一;然而，从意外阿片类药物过量的惊人增加可以看出，其滥用在全球范围内呈上升趋势。这迫切需要增加科学努力，以更好地了解阿片类药物成瘾的主要细胞机制和电路。临床前研究强烈表明，与积极和消极阿片类药物经验相关的记忆在促进强迫性阿片寻求和阿片类药物服用行为以及复发方面至关重要。在过去的二十年里，作为学习和记忆的细胞相关物的突触可塑性在药物成瘾领域得到了迅速的发展。几个关键的成瘾相关的大脑区域被确定，其中之一是腹侧被盖区（VTA），一个区域作为药物奖励的初始位点被深入研究。在这里，我们提供了一个更新，我们以前的审查“阿片类药物和可塑性”突出了最新发现的突触可塑性与阿片类药物在腹侧被盖区。迄今为止，成瘾可塑性的电生理学研究在解决动机和成瘾行为的基础学习过程和机制方面具有非常宝贵的价值，现在随着转基因方法和光遗传学的强大技术的可用性，基于电路的研究在促进阿片类药物成瘾的突触研究方面具有很高的前景。
Opioids are among the most effective pain relievers; however, their abuse has been on the rise worldwide evident from an alarming increase in accidental opioid overdoses. This demands for an urgent increase in scientific endeavors for better understanding of main cellular mechanisms and circuits involved in opiate addiction. Preclinical studies strongly suggest that memories associated with positive and negative opioid experiences are critical in promoting compulsive opiate-seeking and opiate-taking behaviors, and relapse. Particular focus on synaptic plasticity as the cellular correlate of learning and memory has rapidly evolved in drug addiction field over the past two decades. Several critical addiction-related brain areas are identified, one of which is the ventral tegmental area (VTA), an area intensively studied as the initial locus for drug reward. Here, we provide an update to our previous review on “Opiates and Plasticity” highlighting the most recent discoveries of synaptic plasticity associated with opiates in the VTA. Electrophysiological studies of plasticity of addiction to date have been invaluable in addressing learning processes and mechanisms that underlie motivated and addictive behaviors, and now with the availability of powerful technologies of transgenic approaches and optogenetics, circuit-based studies hold high promise in fostering synaptic studies of opiate addiction.
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影响因子：
5.3
作者：
Borgland, SL;Malenka, RC;Bonci, A
通讯作者：
Bonci, A
影响因子：
25
作者：
Edwards, Nicholas J.;Tejeda, Hugo A.;Bonci, Antonello
通讯作者：
Bonci, Antonello
影响因子：
16.2
作者：
Borgland, SL;Taha, SA;Bonci, A
通讯作者：
Bonci, A
影响因子：
16.2
作者：
Authement, Michael E.;Kodangattil, Jayaraj N.;Nugent, Fereshteh S.
通讯作者：
Nugent, Fereshteh S.
影响因子：
3.4
作者：
Bellone, C;Lüscher, C
通讯作者：
Lüscher, C