Influence of apolipoprotein E genotype on cerebral amyloid angiopathy in the elderly
Influence of apolipoprotein E genotype on cerebral amyloid angiopathy in the elderly
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DOI：
10.1161/01.str.27.2.216
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发表时间：
1996-02-01
期刊：
影响因子：
8.3
通讯作者：
Otomo, E
中科院分区：
文献类型：
--
作者：
Itoh, Y;Yamada, M;Otomo, E
背景与目的载脂蛋白E基因（apoliproteinE gene，APOE）等位基因的遗传与阿尔茨海默型痴呆（dementia of the Alzheimer type，DAT）的发病风险增加有关。我们研究了APOE基因型是否影响老年人脑淀粉样血管病（CAA）的严重程度，无论是否有DAT。我们研究了88名患者，（85+/-8.1岁）无除DAT以外的退行性疾病。计算枕叶中淀粉样血管的百分比，并比较APOE基因型之间的差异。在非DAT患者中，CAA在103/4个体中有增加的趋势，而在DAT患者中，CAA在103/3个体中有增加的趋势，但这些趋势均未达到显著性。
Background and Purpose The inheritance of the epsilon 4 allele of the apoliprotein E gene (APOE) is associated with increased risk of developing dementia of the Alzheimer type (DAT). We have investigated whether the APOE genotype influences the severity of cerebral amyloid angiopathy (CAA) in elderly individuals with or without DAT.Methods From a consecutive autopsy series, we studied 88 patients (85+/-8.1 years) without degenerative disorders other than DAT. The percentages of amyloid-laden vessels in the occipital lobes were calculated and compared between APOE genotypes.Results For epsilon 3/3 and epsilon 3/4 genotypes, there was a trend toward increased CAA in epsilon 3/4 individuals for non-DAT and coversely in epsilon 3/3 individuals for DAT patients, but these did not achieve significance.Conclusions The present study suggests that the epsilon 4 allele is not a strong risk factor for CAA in elderly people.