Effect of Bacoside Extract from Bacopa monniera on Physical Fatigue Induced by Forced Swimming
Effect of Bacoside Extract from Bacopa monniera on Physical Fatigue Induced by Forced Swimming
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DOI：
10.1002/ptr.3611
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发表时间：
2012-04-01
影响因子：
7.2
通讯作者：
Bawa, A. S.
中科院分区：
文献类型：
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作者：
Anand, T.;Kumar, G. Phani;Bawa, A. S.
研究了假马齿苋皂甙提取物（BME）的抗疲劳作用。韦茨特被查大鼠进行负重强迫游泳试验（WFST），每隔一天，持续3？周BME剂量为10？mg/kg体重口服给药2？游泳时间、体重变化、脂质过氧化、乳酸（LA）、糖原、抗氧化酶活性（如超氧化物歧化酶（SOD）和过氧化氢酶（CAT））以及血液参数（即血尿素氮（BUN）和肌酸激酶（CK））。在第13天，补充BME的组中的力竭游泳时间与对照组相比增加了3倍。BME组大鼠脑、肝和肌肉组织中丙二醛（MDA）含量分别比运动对照组降低11.2%、16.2%和37.7%（p <0.05）。
The antifatigue effect of bacoside extract (BME) from Bacopa monniera (L.) Wettst. was investigated. Rats were subjected to weight-loaded forced swim test (WFST) every alternate day for 3?weeks. The BME at a dosage of 10?mg/kg body weight was administered orally to rats for 2?weeks in order to evaluate the following biomarkers of physical fatigue: swimming time, change in body weight, lipid peroxidation, lactic acid (LA), glycogen, antioxidant enzyme activities such as superoxide dismutase (SOD) and catalase (CAT) and blood parameters, namely blood urea nitrogen (BUN) and creatine kinase (CK). The exhaustive swimming time was increased by 3-fold in the BME supplemented group compared with that of the control group on day 13. The BME treatment lowered malondialdehyde (MDA) levels in brain, liver and muscle tissues by 11.2%, 16.2% and 37.7%, respectively, compared with the control exercised group (p?