Acquired self-control of insula cortex modulates emotion recognition and brain network connectivity in schizophrenia
Acquired self-control of insula cortex modulates emotion recognition and brain network connectivity in schizophrenia
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DOI：
10.1002/hbm.21427
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发表时间：
2013-01-01
影响因子：
4.8
通讯作者：
Sitaram, Ranganatha
中科院分区：
文献类型：
--
作者：
Ruiz, Sergio;Lee, Sangkyun;Sitaram, Ranganatha
实时功能磁共振成像（rtfMRI）是一种新技术，可以让受试者实现限制大脑区域的自我调节。尽管其预期具有治疗效果，但尚无关于该技术在精神病人群中成功应用的报道。本研究的目的是训练精神分裂症患者在多天内实现双侧前岛叶皮质的意志控制，并探讨习得的自我调节对面部情绪识别（精神分裂症中广泛研究的缺陷）和大脑网络连接的影响。通过为期两周的训练，九名精神分裂症患者接受了通过随机 rtfMRI 神经反馈调节双侧前岛叶血流动力学反应的培训。在训练阶段结束时，患者执行面部情绪识别任务，以探索习得的自我调节的行为效果。双侧前岛叶存在自我调节的学习效应，并且这种效应在训练过程中持续存在。成功的自我调节后，患者识别厌恶面孔的准确度更高，而识别快乐面孔的准确度则较差。厌恶识别的改善与右脑岛的自我激活水平相关。 RtfMRI 训练导致前岛叶传入和传出有效连接数量的增加。这项研究首次表明，精神分裂症患者可以通过 rtfMRI 反馈训练来学习大脑意志调节，从而改变情绪感知和大脑网络连接的调节。这些发现为 rtfMRI 在严重精神病人群中的进一步研究以及可能的治疗应用打开了大门。 Hum Brain Mapp，2013。(c) 2011 Wiley periodicals, Inc.
Real-time functional magnetic resonance imaging (rtfMRI) is a novel technique that has allowed subjects to achieve self-regulation of circumscribed brain regions. Despite its anticipated therapeutic benefits, there is no report on successful application of this technique in psychiatric populations. The objectives of the present study were to train schizophrenia patients to achieve volitional control of bilateral anterior insula cortex on multiple days, and to explore the effect of learned self-regulation on face emotion recognition (an extensively studied deficit in schizophrenia) and on brain network connectivity. Nine patients with schizophrenia were trained to regulate the hemodynamic response in bilateral anterior insula with contingent rtfMRI neurofeedback, through a 2-weeks training. At the end of the training stage, patients performed a face emotion recognition task to explore behavioral effects of learned self-regulation. A learning effect in self-regulation was found for bilateral anterior insula, which persisted through the training. Following successful self-regulation, patients recognized disgust faces more accurately and happy faces less accurately. Improvements in disgust recognition were correlated with levels of self-activation of right insula. RtfMRI training led to an increase in the number of the incoming and outgoing effective connections of the anterior insula. This study shows for the first time that patients with schizophrenia can learn volitional brain regulation by rtfMRI feedback training leading to changes in the perception of emotions and modulations of the brain network connectivity. These findings open the door for further studies of rtfMRI in severely ill psychiatric populations, and possible therapeutic applications. Hum Brain Mapp, 2013. (c) 2011 Wiley Periodicals, Inc.