Cited2 regulates proliferation and survival in young and old mouse cardiac stem cells
Cited2 regulates proliferation and survival in young and old mouse cardiac stem cells
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Cited2 调节年轻和年老小鼠心脏干细胞的增殖和存活
DOI：
10.1186/s12860-019-0207-2
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发表时间：
2019-07-17
影响因子：
2.8
通讯作者：
Zhou, Zuping
中科院分区：
文献类型：
--
作者：
Wu, Qiong;Liu, Qin;Zhou, Zuping
背景：心脏干细胞具有年龄依赖性。Cited2在心脏发育过程中起着重要的调控作用，但Cited2对CSC衰老的影响尚不清楚。结论：Cited2基因在衰老过程中对细胞周期进程和维持细胞增殖与凋亡之间的平衡起重要作用，但不影响细胞的命运决定。这些发现对基于细胞的心脏修复疗法具有重要意义。
Background:Cardiac stem cells (CSCs) exhibit age-dependent characteristics. Cited2 has been implicated in the regulation of heart development; however, there is little known about how Cited2 affects CSC aging.Results:Cited2 mRNA and protein level was downregulated in aging heart tissue and CSCs. Old (O)-CSCs showed decreased differentiation and proliferation capacities as compared to Young (Y)-CSCs, the decrease in cell proliferation, increase in apoptosis, and cell cycle arrest in G0/G1 phase in CSCs are mediated by knocdown CITED2expression in (Y)-CSCs.Conclusions:Cited2 plays an important role in cell cycle progression and in maintaining the balance between CSC proliferation and apoptosis in the process of aging without influencing cell fate decisions. These findings have important implications for cell-based therapies for heart repair.