TubercuList-10 years after
TubercuList-10 years after
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DOI：
10.1016/j.tube.2010.09.008
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发表时间：
2011-01-01
期刊：
影响因子：
3.2
通讯作者：
Cole, Stewart T.
中科院分区：
文献类型：
--
作者：
Lew, Jocelyne M.;Kapopoulou, Adamandia;Cole, Stewart T.
TubercuList(http://tuberculist.epfl.ch/)，)是一个关系数据库，提供关于结核分枝杆菌范例菌株H37Rv的基因组衍生信息，已经活跃了十年，现在发布了它的第二十个版本。在这里，我们描述了一些最近的变化，这些变化是通过使用科学文献中的信息进行手动注释而产生的。通过人工管理，TubercuList努力提供最新的基于基因的信息，因此有别于其他结核分枝杆菌基因组序列数据的在线来源。当生物信息学或实验数据表明这是必需的时，已经发现了新的、大多是小的基因，一些现有编码序列的坐标已经改变。对H37Rv不同来源之间多态的核苷酸进行了注释，并更新了基因重要性数据。从文献中收集了大量的功能信息，并包括了许多新的蛋白质和RNA的活性。为了促进基础和翻译研究，TubercuList还提供到其他专业数据库的链接，这些数据库提供了各种数据集，如3D结构、表达谱、药物开发标准和耐药性信息，此外还提供了直接访问与特定基因相关的PubMed文章的链接。对于结核病研究社区来说，TubercuList一直是一个非常有价值的工具，每月有75,000个访问者。(C)2010爱思唯尔有限公司。保留所有权利。
TubercuList (http://tuberculist.epfl.ch/), the relational database that presents genome-derived information about H37Rv, the paradigm strain of Mycobacterium tuberculosis, has been active for ten years and now presents its twentieth release. Here, we describe some of the recent changes that have resulted from manual annotation with information from the scientific literature. Through manual curation, TubercuList strives to provide current gene-based information and is thus distinguished from other online sources of genome sequence data for M. tuberculosis. New, mostly small, genes have been discovered and the coordinates of some existing coding sequences have been changed when bioinformatics or experimental data suggest that this is required. Nucleotides that are polymorphic between different sources of H37Rv are annotated and gene essentiality data have been updated. A host of functional information has been gleaned from the literature and many new activities of proteins and RNAs have been included. To facilitate basic and translational research, TubercuList also provides links to other specialized databases that present diverse datasets such as 3D-structures, expression profiles, drug development criteria and drug resistance information, in addition to direct access to PubMed articles pertinent to particular genes. TubercuList has been and remains a highly valuable tool for the tuberculosis research community with >75,000 visitors per month. (C) 2010 Elsevier Ltd. All rights reserved.