Fruit and vegetable consumption in relation to pancreatic cancer risk:: A prospective study
Fruit and vegetable consumption in relation to pancreatic cancer risk:: A prospective study
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DOI：
10.1158/1055-9965.epi-05-0696
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发表时间：
2006-02-01
影响因子：
3.8
通讯作者：
Wolk, A
中科院分区：
文献类型：
--
作者：
Larsson, SC;Håkansson, N;Wolk, A
在许多病例对照研究中，大量食用水果和蔬菜与较低的胰腺癌风险相关。然而，关于这种关系的队列研究有限且不支持这种关联。我们在瑞典乳腺X线摄影队列和瑞典男性队列的81922名女性和男性中，研究了水果和蔬菜总体摄入量以及某些水果和蔬菜亚组的摄入量与胰腺癌发病率的关系。使用Cox比例风险模型估计了具有95%置信区间（95%CI）的风险比（HR）。在平均6.8年（1998 - 2004年）的随访期间，诊断出135例胰腺癌新发病例。在对年龄和其他胰腺癌风险因素进行调整后，与最低摄入量类别相比，最高摄入量类别的风险比分别为：水果和蔬菜总量为1.13（95%CI，0.66 - 1.94），水果总量为1.10（95%CI，0.64 - 1.88），蔬菜总量为1.08（95%CI，0.63 - 1.85）。在水果和蔬菜的特定亚组中，十字花科蔬菜的摄入量观察到一种不显著的负相关（每周≥3份与每周<1份相比：HR，0.70；95%CI，0.43 - 1.13）。卷心菜的摄入量与胰腺癌风险在统计学上显著降低相关（每周≥1份与从不食用相比：HR，0.62；95%CI，0.39 - 0.99）。这项前瞻性研究的结果不支持水果和蔬菜总体摄入量与胰腺癌风险之间的关系。十字花科蔬菜摄入量与胰腺癌风险之间的关联值得进一步研究。
High consumption of fruits and vegetables has been associated with a lower risk of pancreatic cancer in many case-control studies. However, cohort studies on this relationship are limited and do not support an association. We examined the associations of overall consumption of fruits and vegetables and consumption of certain subgroups of fruits and vegetables with the incidence of pancreatic cancer among 81,922 women and men in the Swedish Mammography Cohort and the Cohort of Swedish Men. Hazard ratios (HR) with 95% confidence intervals (95% CI) were estimated using Cox proportional hazards models. During an average follow-up of 6.8 years (1998-2004), 135 incident pancreatic cancer cases were diagnosed. After adjustment for age and other risk factors for pancreatic cancer, the HRs for the highest compared with the lowest category of intake were 1.13 (95% Cl, 0.66-1.94) for total fruits and vegetables, 1.10 (95% CI, 0.64-1.88) for total fruits, and 1.08 (95% CI, 0.63-1.85) for total vegetables. Among specific subgroups of fruits and vegetables, a nonsignificant inverse association was observed with cruciferous vegetable consumption G (>= 3 servings/wk versus < 1 serving/wk: HR, 0.70; 95% Cl, 0.43-1.13). Cabbage consumption was associated with a statistically significant lower risk of pancreatic cancer (>= 1 serving/wk versus never consumption: HR, 0.62; 95% Cl, 0.39-0.99). Findings from this prospective study do not support a relationship of overall fruit and vegetable consumption with pancreatic cancer risk. The association between consumption of cruciferous vegetables and pancreatic cancer risk warrants further investigation.