Relation of serum lipoprotein lipids and apolipoproteins to obesity in children: the Bogalusa Heart Study.
Relation of serum lipoprotein lipids and apolipoproteins to obesity in children: the Bogalusa Heart Study.
复制标题
血清脂蛋白脂质和载脂蛋白与儿童肥胖的关系：Bogalusa 心脏研究。
DOI：
10.1016/0091-7435(92)90017-c
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发表时间：
1992
影响因子：
5.1
通讯作者：
Berenson,GS
中科院分区：
文献类型：
--
作者：
Kikuchi,DA;Srinivasan,SR;Harsha,DW;Webber,LS;Sellers,TA;Berenson,GS
背景资料。对路易斯安那州博加卢萨市2816名5-17岁儿童的血清脂蛋白和载脂蛋白与肥胖的关系进行了研究。肥胖的两个衡量标准是：肥胖度(肩胛下皮褶厚度)和脂肪中心性(肩胛骨下皮褶厚度与三头肌皮褶厚度的比率)。将血浆胰岛素和血糖作为与肥胖相关的代谢指标。肥胖与胰岛素(RS=0.29，P<；0.001，皮褶比；RS=0.15，P<；0.001，皮褶比)和甘油三酯(RS=0.25，P<；0.001，皮褶比；RS=0.19，P<；0.001，皮褶比)有较强的相关性。血清低密度脂蛋白胆固醇(RS=0.17，P<；0.001，皮褶比；RS=0.12，P<；0.001，皮褶比)和载脂蛋白B(RS=0.16，P<；0.001，皮褶比；RS=0.13，P<；0.001，皮褶比)与肥胖指标的关系较小，但在调整胰岛素和甘油三酯后仍持续存在。只有在调整胰岛素和血清甘油三酯后，肥胖与血清高密度脂蛋白胆固醇(RS=−0.13，P<；0.001，皮褶和皮褶比率)和载脂蛋白A-I(RS=−0.04，P=0.03，皮褶比率；RS=−0.05，P=0.004，皮褶比率)呈显著负相关。肥胖测量的多元线性回归表明，与胰岛素一样，血清甘油三酯的标准化系数始终高于低密度脂蛋白-C、高密度脂蛋白-C、载脂蛋白B和载脂蛋白A-I。载脂蛋白A-I和载脂蛋白B仅增加了少量(2%)血清脂蛋白与肥胖测量之间的关系。这些结果表明，血清极低密度脂蛋白(VLDL)水平与肥胖直接和独立相关。众所周知，肥胖和血清高密度脂蛋白-C之间的负相关不是独立的，而是次要的，与肥胖相关的极低密度脂蛋白或甘油三酯水平升高。虽然肥胖与脂蛋白胆固醇有关，但与载脂蛋白，尤其是载脂蛋白A-I有关的情况要少得多。在肥胖与血清脂蛋白和载脂蛋白的关系中，有趣的种族和性别差异被注意到，在白人儿童中更明显，在白人男性中更一致。
Background. The relationship of serum lipoprotein lipids and apolipoproteins to obesity was studied in a biracial sample of 2,816 children of ages 5–17 in Bogalusa, Louisiana.Methods. Two measures of obesity were used: fatness (subscapular skinfold thickness) and fat centrality (the ratio of subscapular to triceps skinfold thickness). Plasma insulin and glucose were included as metabolic markers related to obesity.Results. The obesity associations were relatively strong with insulin (rs= 0.29,P< 0.001, skinfold;rS= 0.15,P< 0.001, skinfold ratio) and triglycerides (rS= 0.25,P< 0.001, skinfold;rS= 0.19,P< 0.001, skinfold ratio). The relationships of serum low-density lipoprotein cholesterol (LDL-C) (rS= 0.17,P< 0.001, skinfold;rS= 0.12,P< 0.001, skinfold ratio)and apolipoprotein (apo) B (rS= 0.16,P< 0.001, skinfold;rS= 0.13,P< 0.001, skinfold ratio) with the obesity measures were of lesser magnitude, but persisted after adjustment for insulin and triglycerides. The inverse association of obesity to serum high-density lipoprotein cholesterol (HDL-C) (rS= −0.13,P< 0.001, both skinfold and skinfold ratio) and apo A-I (rS= −0.04,P= 0.03, skinfold;rS= −0.05,P= 0.004, skinfold ratio) was significant only before adjustment for insulin and serum triglycerides. Multiple linear regression of obesity measures showed that, like insulin, serum triglycerides had consistently higher standardized coefficients than LDL-C, HDL-C, apo B, and apo A-I. Apo A-I and apo B added only a small amount (<2%) of information to the relationship of serum lipoproteins with obesity measures.Conclusion. These results indicate that serum very-low-density lipoprotein (VLDL) levels are directly and independently related to obesity. The well-known inverse association between obesity and serum HDL-C is not independent, but secondary to the elevated VLDL or triglyceride levels associated with obesity. While associations of obesity and lipoprotein cholesterol are found, far fewer occur with apolipoproteins, especially Apo A-I. Interesting race and sex differences in the relationship of obesity to serum lipoproteins and apoproteins are noted, being greater among white children and more consistent in white males.