The magnetic properties and structure of hemoglobin, oxyhemoglobin and carbonmonoxyhemoglobin
The magnetic properties and structure of hemoglobin, oxyhemoglobin and carbonmonoxyhemoglobin
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DOI：
10.1073/pnas.22.4.210
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发表时间：
1936-01-01
影响因子：
11.1
通讯作者：
Coryell, CD
中科院分区：
文献类型：
--
作者：
Pauling, L;Coryell, CD
90多年前，1845年11月8日，迈克尔·法拉第（Michael Faraday）研究了干血的磁性，并记下了“必须尝试最近的液体血液”。如果他测定了动脉血和静脉血的磁化率，他会发现它们有很大的差异（完全含氧和完全缺氧的血液相差20%）；这一发现无疑会引起极大的兴趣，并对血液和血红蛋白的研究进程产生重大影响。继续我们对血红蛋白和相关物质的磁性和结构的研究，我们发现氧合血红蛋白和单氧合血红蛋白不含不成对电子，而铁血红蛋白（血红蛋白本身）每个血红素含有四个不成对电子。我们的实验描述和结果的解释和讨论如下。关于命名法的说明。血红蛋白和相关物质的现行命名法是在没有关于这些物质的化学成分和结构的精确信息的时候制定的。既然在收集这些信息方面，特别是在化学成分方面，已经取得了一些进展，就有可能修改命名法，使物质的名称比旧的名称更具描述性，而不引起任何根本性的变化。在制定以下一系列名称时，我们受益于艾尔弗雷德·e·米尔斯基博士的持续建议。
Over ninety years ago, on November 8, 1845, Michael Faraday investigated the magnetic properties of dried blood and made a note" Must try recent fluid blood." If he had determined the magnetic susceptibilities of arterial and venous blood, he would have found them to differ by a large amount (as much as twenty per cent for completely oxygenated and completely deoxygenated blood); this discovery without doubt would have excited much interest and would have influenced appreciably the course ofresearch on blood and hemoglobin. 1 Continuing our investigations of the magnetic properties and structure of hemoglobin and related substances, 2 we have found oxyhemoglobin and carbonmonoxyhemoglobin to contain no unpaired electrons, and ferrohemoglobin (hemoglobin itself) to contain four unpaired electrons per heme. The description of our experiments and the interpretation and discussion of the results are given below.Note on Nomenclature.-The current nomenclature of hemoglobin and related sub-stances was formulated at a time when, precise information about the chemical composition and structure of the substances was not available. Now that some progress has been made in gathering this information, especially in regard to chemical composition, it is possible to revise the nomenclature in such a way as to make the names ofsubstances more descriptive than the older names, without introducing any radical changes. In formulating the following set of names we haveprofited by thecontinued advice of Dr. Alfred E. Mirsky.