RELEASE OF MEDIATORS OF ANAPHYLAXIS: INHIBITION OF PROSTAGLANDIN SYNTHESIS AND THE MODIFICATION OF RELEASE OF SLOW REACTING SUBSTANCE OF ANAPHYLAXIS AND HISTAMINE
RELEASE OF MEDIATORS OF ANAPHYLAXIS: INHIBITION OF PROSTAGLANDIN SYNTHESIS AND THE MODIFICATION OF RELEASE OF SLOW REACTING SUBSTANCE OF ANAPHYLAXIS AND HISTAMINE
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过敏反应介质的释放：抑制前列腺素合成以及改变过敏反应慢反应物质和组胺的释放
DOI：
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发表时间：
1978
影响因子：
7.3
通讯作者：
P. Sirois
中科院分区：
文献类型：
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作者：
D. Engineer;U. Niederhauser;P. Piper;P. Sirois
1 当用抗原攻击来自致敏豚鼠的离体灌注肺时，组胺、过敏反应慢反应物质 (SRS-A) 和前列腺素样物质被释放到流出物中。 2 在攻击前和攻击期间用吲哚美辛 (0.5–10 μg/ml)、阿司匹林钠 (1–10 μg/ml)、甲氯芬那酸钠 (0.1–1 μg/ml) 或酮洛芬 (0.5–5 μg/ml) 对肺部进行治疗，可抑制前列腺素的释放，同时使组胺和 SRS-A 的输出增加三到五倍。 3 二乙基卡马嗪 (0.2–1 mg/ml) 减少了 SRS-A 和组胺的释放，但增加了前列腺素样物质的产生量。 4 二十碳四烯酸 (10 μg/ml) 抑制前列腺素的形成，但不改变组胺和 SRS-A 的释放。 5 非类固醇抗炎药和二乙基卡马嗪的结果表明，前列腺素或环加氧酶系统的某些其他产物可抑制 SRS-A 和组胺的过敏性释放。
1 When isolated perfused lungs from sensitized guinea‐pigs were challenged with antigen, histamine, slow reacting substance of anaphylaxis (SRS‐A) and prostaglandin‐like substances were released into the effluent. 2 Treatment of the lungs before and during challenge with indomethacin (0.5–10 μg/ml), sodium aspirin (1–10 μg/ml), sodium meclofenamate (0.1–1 μg/ml) or ketoprofen (0.5–5 μg/ml) inhibited the release of prostaglandins while increasing the output of histamine and SRS‐A between three‐and five‐fold. 3 Diethylcarbamazine (0.2–1 mg/ml) reduced the release of SRS‐A and histamine but increased the amount of prostaglandin‐like substances produced. 4 Eicosatetraynoic acid (10 μg/ml) inhibited formation of prostaglandins but did not modify release of histamine and SRS‐A. 5 The results with non‐steroid anti‐inflammatory drugs and diethylcarbamazine suggest that prostaglandins, or some other product of the cyclo‐oxygenase system, depress the anaphylactic release of SRS‐A and histamine.