Chromosome abnormalities may correlate with prognosis in Burkitt/Burkitt-like lymphomas of children and adolescents - A report from children's cancer group study CCG-E08
Chromosome abnormalities may correlate with prognosis in Burkitt/Burkitt-like lymphomas of children and adolescents - A report from children's cancer group study CCG-E08
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DOI：
10.1097/00043426-200403000-00006
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发表时间：
2004-03-01
影响因子：
1.2
通讯作者：
Cairo, MS
中科院分区：
文献类型：
--
作者：
Lones, MA;Sanger, WG;Cairo, MS
在小儿非霍奇金淋巴瘤中，最常见的类型是小非裂解细胞淋巴瘤（包括伯基特和伯基特样）。特定染色体异常与儿童急性淋巴细胞白血病（ALL）的预后相关;然而，尚未评估染色体异常对儿童伯基特和伯基特样淋巴瘤的预后价值。对于儿童癌症组方案CCG-E-08儿童非霍奇金淋巴瘤病因学研究，19例患者入组伯基特或伯基特样淋巴瘤的细胞遗传学分析，同时入组治疗方案CCG-503或CCG-552。对初次诊断时的病理学材料和核型进行了中心审查。人口统计学包括年龄范围为2 - 14岁（中位年龄为8岁），男女比例为14：5。所有患者均患有晚期疾病（III期和IV期，或ALL）。5例患者疾病复发（无事件生存率74%，中位随访时间10.4年）。18例患者（95%）发现染色体异常，包括12例（63%）的t（8; 14）（q24.1;q32）; 1例（5%）的t（8;22）（q24.1; q11.2）; 7例（37%）的1个q部分重复; 2例（11%）的13 q32异常。在复发的患者中，除了t（8; 14）（q24.1;q32），2例13 q32异常，2例1 q部分重复。所有三名患者的伯基特样淋巴瘤中均不存在CMYC易位。儿童伯基特和伯基特样淋巴瘤染色体异常的频率很高。伯基特淋巴瘤异常通常涉及CMYC易位，通常为t（8; 14）（q24.1;q32）。涉及13 q32和I q部分重复的额外染色体异常与不良预后相关。伯基特样淋巴瘤与CMYC易位无关。进一步的研究是必要的，在更大的队列的儿童和青少年与伯基特和伯基特样淋巴瘤。
Among pediatric non-Hodgkin lymphomas, the most frequent type is small noncleaved-cell lymphoma (including Burkitt and Burkitt-like). Specific chromosome abnormalities are associated with prognosis in childhood acute lymphoblastic leukemia (ALL); however, chromosome abnormalities have not been evaluated for prognostic value in pediatric Burkitt and Burkitt-like lymphomas. For Children's Cancer Group protocol CCG-E-08 Etiologic Study of Non-Hodgkin Lymphoma in Childhood, 19 patients were enrolled with cytogenetic analysis of Burkitt or Burkitt-like lymphoma and simultaneously enrolled on treatment protocols CCG-503 or CCG-552. Pathology material and karyotypes at initial diagnosis underwent central review. Demographics included an age range of 2 to 14 years (median 8 years) and a male:female ratio of 14:5. All patients had advanced disease (stages III and IV, or ALL). Disease relapsed in five patients (event-free survival 74%, median follow-up 10.4 years). Chromosome abnormalities were identified in 18 patients (95%) including t(8; 14)(q24.1;q32) in 12 (63%); t(8;22)(q24.1;q 11.2) in 1 (5%); partial duplication of 1 q in 7 (37%); and 13q32 abnormalities in 2 (11%). In patients who had relapses, in addition to the t(8; 14)(q24.1;q32), two had abnormalities of 13q32 and two had partial duplication of 1q. CMYC translocations were absent in Burkitt-like lymphomas from all three patients. Burkitt and Burkitt-like lymphomas in children have a high frequency of chromosome abnormalities. Burkitt lymphoma abnormalities often involve CMYC translocations, usually a t(8; 14)(q24.1;q32). Additional chromosome abnormalities that involved 13q32 and partial duplication of I q were associated with poor prognosis. Burkitt-like lymphomas were not associated with CMYC translocations. Further studies are warranted in larger cohorts of children and adolescents with Burkitt and Burkitt-like lymphomas.