Biomechanics of vascular mechanosensation and remodeling.
Biomechanics of vascular mechanosensation and remodeling.
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DOI：
10.1091/mbc.e14-11-1522
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发表时间：
2016-01-01
影响因子：
3.3
通讯作者：
Schwartz MA
中科院分区：
文献类型：
--
作者：
Baeyens N;Schwartz MA
血液流动对血管和淋巴管内皮细胞施加摩擦力，即流体剪切力(FSS)。FSS的大小、脉动性和方向性特征由内皮不断地感觉到。FSS的持续增加或减少可诱导血管重塑，以维持组织的适当灌流。在这篇综述中，我们讨论了这些机制及其与生理和疾病的相关性，并提出了一个如何整合来自不同机械传感器的信息来管理重塑的模型。
Flowing blood exerts a frictional force, fluid shear stress (FSS), on the endothelial cells that line the blood and lymphatic vessels. The magnitude, pulsatility, and directional characteristics of FSS are constantly sensed by the endothelium. Sustained increases or decreases in FSS induce vessel remodeling to maintain proper perfusion of tissue. In this review, we discuss these mechanisms and their relevance to physiology and disease, and propose a model for how information from different mechanosensors might be integrated to govern remodeling.