POTENTIAL EPIDEMIC OF CREUTZFELDT-JAKOB DISEASE FROM HUMAN GROWTH-HORMONE THERAPY
POTENTIAL EPIDEMIC OF CREUTZFELDT-JAKOB DISEASE FROM HUMAN GROWTH-HORMONE THERAPY
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DOI：
10.1056/nejm198509193131205
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发表时间：
1985-01-01
影响因子：
158.5
通讯作者：
ASHER, DM
中科院分区：
文献类型：
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作者：
BROWN, P;GAJDUSEK, DC;ASHER, DM
克雅氏病在脑部或眼部手术中可能会意外地从一个人传染给另一个人。1，2十年后，由于早期使用人类生长激素治疗，医源性克雅氏病再次出现，并有可能迅速蔓延。短短几个月内，美国有三名年轻人死于这种疾病，2例患者经神经病理学证实，1例患者经临床检测但未经证实3;在英国发现了另一例神经病理学证实的病例。4表1总结了这4例病例的显著数据。(The两者的细节……
A DECADE after the demonstration that Creutzfeldt—Jakob disease could be accidentally transmitted from one person to another during brain or eye surgery,1,2iatrogenic Creutzfeldt—Jakob disease has reappeared as a result of earlier therapy with human growth hormone, with the ominous possibility of a burgeoning epidemic.Within just a few months, three young adults in the United States have died from the disease, confirmed neuropathologically in two patients and clinically detected but unconfirmed in one3; an additional neuropathologically confirmed case has been identified in Great Britain.4Salient data on these four cases are summarized in Table 1. (The details of both . . .