Cohorts for the Study of HIV-1-Exposed but Uninfected Individuals: Benefits and Limitations
Cohorts for the Study of HIV-1-Exposed but Uninfected Individuals: Benefits and Limitations
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DOI：
10.1086/655971
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发表时间：
2010-11-01
影响因子：
6.4
通讯作者：
Ball, T. Blake
中科院分区：
文献类型：
--
作者：
Horton, R. E.;McLaren, P. J.;Ball, T. Blake
自20世纪80年代末以来，随着首次发现暴露于人类免疫缺陷病毒1型(HIV-1)但仍未感染或对HIV-1耐药的个人，全球范围内已确定了包括HIV暴露血清阴性(HESN)受试者在内的大量队列，目的是调查可能有助于改变对HIV-1易感性的遗传、免疫学和环境因素。在这篇文章中，结合最近召开的HIV天然免疫国际研讨会，我们回顾了不同人群相对风险的特点，并简要总结了包括全球暴露的未感染对象在内的已知队列。
Since the late 1980s, with the first identification of individuals who were exposed to human immunodeficiency virus type 1 (HIV-1) yet remained uninfected, or "HIV-1-resistant" individuals, a large number of cohorts that include HIV-exposed seronegative (HESN) subjects have been identified globally for the purpose of investigating the genetic, immunologic, and environmental factors that may help alter susceptibility to HIV-1. In this article, in light of the recent International Symposium on Natural Immunity to HIV, we review the characteristics of different groups with respect to their relative risks and briefly summarize the known cohorts that include exposed uninfected subjects worldwide.