In vivo vibrometry inside the apex of the mouse cochlea using spectral domain optical coherence tomography.
In vivo vibrometry inside the apex of the mouse cochlea using spectral domain optical coherence tomography.
复制标题
使用频谱域光学相干断层扫描，在小鼠耳蜗的顶点内的体内振动法。
DOI：
10.1364/boe.4.00230
复制
发表时间：
2013-02-01
影响因子：
3.4
通讯作者：
Oghalai JS
中科院分区：
文献类型：
--
作者：
Gao SS;Raphael PD;Wang R;Park J;Xia A;Applegate BE;Oghalai JS
内耳听觉部分（耳蜗）内的声传导是一个复杂的非线性过程。对大型啮齿动物耳蜗力学的研究为了解耳蜗功能提供了重要的信息。然而，由于技术和实验的限制，小鼠的耳蜗较小，因此限制了对小鼠的研究。这些挑战是重要的克服，因为各种各样的转基因小鼠品系的听力损失突变，可用于研究。为了实现这一目标，我们使用谱域光学相干断层扫描可视化和测量声致振动的脑内组织。我们目前，据我们所知，第一次振动测量从一个未打开的小鼠耳蜗的顶点。
Sound transduction within the auditory portion of the inner ear, the cochlea, is a complex nonlinear process. The study of cochlear mechanics in large rodents has provided important insights into cochlear function. However, technological and experimental limitations have restricted studies in mice due to their smaller cochlea. These challenges are important to overcome because of the wide variety of transgenic mouse strains with hearing loss mutations that are available for study. To accomplish this goal, we used spectral domain optical coherence tomography to visualize and measure sound-induced vibrations of intracochlear tissues. We present, to our knowledge, the first vibration measurements from the apex of an unopened mouse cochlea.