Development of REM and slow wave sleep in the rat
Development of REM and slow wave sleep in the rat
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DOI：
10.1152/ajpregu.1997.272.6.r1792
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发表时间：
1997-06-01
影响因子：
2.8
通讯作者：
Heller, HC
中科院分区：
文献类型：
--
作者：
Frank, MG;Heller, HC
新生儿的主动睡眠（AS）一直被认为是一种不成熟的快速眼动形式！快速眼动睡眠，安静的睡眠！QS）被认为代表了慢波睡眠（SWS）的不成熟形式。为了确定AS和QS的行为确定的状态和电图确定的REM睡眠和SWS之间的关系，我们研究了睡眠个体发育中的大鼠使用的实验程序，允许长期记录，并尽量减少母亲分离的影响。在这种情况下。包括脑电图慢波活动和相位运动活动的瞬态最终被成熟的SWS模式所取代。我们的研究表明，新生儿QS不是SWS的不成熟形式，AS最好被认为是SWS和REM睡眠发展的未分化行为状态。
Active sleep (AS) in the neonate has been considered to be an immature form of rapid eye movement !REM) sleep, Quiet sleep !QS) has been thought to represent an immature form of slow wave sleep (SWS). To determine the relationship between the behaviorally determined states of AS and QS and electrographically determined REM sleep and SWS, we examined sleep ontogeny in the developing rat using an experimental routine that permitted long-term recordings and minimized the effects of maternal separation. Under these conditions. a transient state that included electroencephalographic slow wave activity and phasic motor activity was eventually replaced with the mature SWS pattern. Our work suggests that neonatal QS is not an immature form of SWS and that AS is best considered as an undifferentiated behavioral state from which both SWS and REM sleep develop.