Nanomaterial payload delivery to central nervous system glia for neural protection and repair.
Nanomaterial payload delivery to central nervous system glia for neural protection and repair.
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纳米材料有效载荷交付给中枢神经系统神经胶质，以进行神经保护和修复。
DOI：
10.3389/fncel.2023.1266019
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发表时间：
2023
影响因子：
5.3
通讯作者：
Zuidema, Jonathan M.
中科院分区：
文献类型：
--
作者：
Saksena, Jayant;Hamilton, Adelle E.;Gilbert, Ryan J.;Zuidema, Jonathan M.
关键词：
中枢神经系统（CNS）胶质细胞，包括星形胶质细胞、小胶质细胞和少突胶质细胞，在创伤性损伤和退行性疾病中发挥重要作用。由于其重要性，活性药物成分（api）正被开发用于调节中枢神经胶质细胞，以改善创伤性损伤和疾病的预后。虽然这些原料药中的许多在体外显示出希望，但大多数系统递送的原料药很少穿过血脑屏障（BBB）或血脊髓屏障（BSCB）并进入中枢神经系统，使其无效。新型纳米材料正在被开发，用于将原料药输送到中枢神经系统，以调节神经胶质反应，改善损伤和疾病的预后。纳米材料在退行性疾病和创伤性损伤中作为中枢神经系统保护和修复的治疗方法是有吸引力的选择，因为它们具有原料药递送的内在能力。纳米材料可以通过增加原料药通过血脑屏障的渗透，延长原料药释放的时间，以及由于其力学特性和纳米级结构而与中枢神经系统细胞群发生生物物理相互作用，从而改善原料药在中枢神经系统中的积累。在这篇综述中，我们介绍了局部植入纳米材料和系统给药纳米材料领域的最新进展，这些纳米材料用于向中枢神经系统递送原料药，调节神经胶质活性，作为改善创伤性损伤和疾病预后的策略。我们确定了当前的研究差距，并讨论了该领域的潜在发展，将继续将胶质靶向纳米材料的使用转化为临床。
Central nervous system (CNS) glia, including astrocytes, microglia, and oligodendrocytes, play prominent roles in traumatic injury and degenerative disorders. Due to their importance, active pharmaceutical ingredients (APIs) are being developed to modulate CNS glia in order to improve outcomes in traumatic injury and disease. While many of these APIs show promise in vitro, the majority of APIs that are systemically delivered show little penetration through the blood–brain barrier (BBB) or blood-spinal cord barrier (BSCB) and into the CNS, rendering them ineffective. Novel nanomaterials are being developed to deliver APIs into the CNS to modulate glial responses and improve outcomes in injury and disease. Nanomaterials are attractive options as therapies for central nervous system protection and repair in degenerative disorders and traumatic injury due to their intrinsic capabilities in API delivery. Nanomaterials can improve API accumulation in the CNS by increasing permeation through the BBB of systemically delivered APIs, extending the timeline of API release, and interacting biophysically with CNS cell populations due to their mechanical properties and nanoscale architectures. In this review, we present the recent advances in the fields of both locally implanted nanomaterials and systemically administered nanoparticles developed for the delivery of APIs to the CNS that modulate glial activity as a strategy to improve outcomes in traumatic injury and disease. We identify current research gaps and discuss potential developments in the field that will continue to translate the use of glia-targeting nanomaterials to the clinic.
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DOI：
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