Dynamic encoding of saccade sequences in primate frontal eye field
Dynamic encoding of saccade sequences in primate frontal eye field
复制标题
灵长类动物额眼场扫视序列的动态编码
DOI：
10.1113/jp282094
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Chen Aihua
中科院分区：
文献类型：
--
作者：
Jia Jing;Puyang Zhen;Wang Qingjun;Jin Xin;Chen Aihua
摘要：额叶视野（FEF）是动眼神经系统的关键部分，对单次眼跳的方向具有主导反应。然而，FEF 是否以及如何促进连续眼跳仍然很大程度上未知。通过训练恒河猴执行眼跳序列，我们发现 FEF 神经元中存在与序列相关的活动，其对眼跳方向的选择性在顺序运动期间经历动态变化。单次眼跳。这些与序列相关的活动是上下文相关的，在记忆与记忆过程中表现出不同的激发活动。视觉引导序列。当猴子执行顺序扫视任务时，与固定条件相比，FEF中诱发扫视的微刺激阈值增加，成功诱发扫视的百分比显着降低。 FEF 的药理学失活损害了猴子先前习得的连续眼跳的表现，根据其在序列中的位置，对相同动作产生不同的影响。这些结果揭示了 FEF 中扫视的上下文相关、序列特定的动态编码，并强调了 FEF 在顺序扫视的计划和执行中的关键作用。要点FEF 神经元在顺序扫视期间与单次扫视期间的响应不同序列相关的 FEF 活动是上下文相关的FEF 中的微刺激阈值在顺序任务期间增加，但诱发的扫视并没有改变序列结构FEF 失活严重损害了顺序扫视的性能眼跳
AbstractThe frontal eye field (FEF) is a key part of the oculomotor system, with dominant responses to the direction of single saccades. However, whether and how FEF contributes to sequential saccades remain largely unknown. By training rhesus monkeys to perform saccade sequences, we found sequence‐related activities in FEF neurons, whose selectivity to saccade direction undergoes dynamic changes during sequentialvs. single saccades. These sequence‐related activities are context‐dependent, exhibiting different firing activities during memory‐vs. visually guided sequences. When the monkey was performing the sequential saccade task, the thresholds of microstimulation to evoke saccades in FEF were increased and the percentage of the successfully induced saccades was significantly reduced compared with the fixation condition. Pharmacological inactivation of FEF impaired the monkey's performance of previously learned sequential saccades, with different effects on the same actions depending on its position within the sequence. These results reveal the context‐dependent, sequence‐specific dynamic encoding of saccades in FEF, and underscore the crucial role of FEF in the planning and execution of sequential saccades.Key pointsFEF neurons respond differently during sequential vs. single saccadesSequence‐related FEF activity is context‐dependentThe microstimulation threshold in FEF was increased during the sequential task but the evoked saccade did not alter the sequence structureFEF inactivation severely impaired the performance of sequential saccades