ABDOMINAL SEGMENTATION, POLE CELL-FORMATION, AND EMBRYONIC POLARITY REQUIRE THE LOCALIZED ACTIVITY OF OSKAR, A MATERNAL GENE IN DROSOPHILA
ABDOMINAL SEGMENTATION, POLE CELL-FORMATION, AND EMBRYONIC POLARITY REQUIRE THE LOCALIZED ACTIVITY OF OSKAR, A MATERNAL GENE IN DROSOPHILA
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DOI：
10.1016/0092-8674(86)90375-2
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发表时间：
1986-10-10
期刊：
影响因子：
64.5
通讯作者：
NUSSLEINVOLHARD, C
中科院分区：
文献类型：
--
作者：
LEHMANN, R;NUSSLEINVOLHARD, C
来自奥斯卡雌虫的胚胎缺乏极细胞和包括极粒在内的特化极浆。此外，腹部区域保持不分割并最终死亡。将正常胚胎的细胞质移植到突变胚胎中，揭示了osk依赖的活性严格定位于后极，并具有三种不同的功能。在突变胚胎中，当移植到后极时，活性将使极细胞形成正常化，并且在移植到更前部的预期腹部区域后，使腹部分割正常化。此外，osk的活动还可以在大脑前部形成第二个“后中枢”。osk产物参与后极细胞质中形态发生活性的来源的建立。
Embryos derived from oskar females lack pole cells and the specialized pole plasm including polar granules. In addition, the abdominal region remains unsegmented and eventually dies. Transplantation of cytoplasm from normal embryos into mutant embryos reveals that osk-dependent activity is strictly localized at the posterior pole and has three distinct functions. In mutant embryos the activity will normalize pole cell formation when transplanted into the posterior pole and abdominal segmentation after transplantation to a more anterior, the prospective abdominal, region. Furthermore, osk activity can provoke the formation of a second " posterior center" at the anterior. The participation of the osk product in the establishment of a source of morphogenetic activity in the posterior pole plasm is discussed.