β-amyloid imaging and memory in non-demented individuals:: evidence for preclinical Alzheimer's disease
β-amyloid imaging and memory in non-demented individuals:: evidence for preclinical Alzheimer's disease
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DOI：
10.1093/brain/awm238
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发表时间：
2007-11-01
期刊：
影响因子：
14.5
通讯作者：
Rowe, Christopher C.
中科院分区：
文献类型：
--
作者：
Pike, Kerryn E.;Savage, Greg;Rowe, Christopher C.
β -淀粉样蛋白（A β）沉积是阿尔茨海默病（AD）的病理特征，但可能发生在正常老年人中，没有明显的认知影响。情景记忆障碍是阿尔茨海默病的早期和突出症状，但在非痴呆者和阿尔茨海默病患者中，其与A β负担的关系尚不清楚。我们使用C-11-PIB-PET作为健康衰老（HA）、轻度认知障碍（MCI）和AD体内a β负荷的定量标记物来研究这种关系。31名AD、33名MCI和32名HA参与者完成了神经心理学评估和C-11-PIB-PET脑部扫描。对情景记忆表现和其他认知功能与A β负担的关系进行多元线性回归分析。97%的AD、61%的MCI和22%的HA患者皮质PIB结合增加，表明存在A β斑块。在MCI和HA中，受损的情景记忆表现和PIB结合之间存在很强的关系。这种关系在阿尔茨海默病中较弱，在非记忆认知领域则较弱。无症状老年人的β沉积与情景记忆障碍有关。这一发现，再加上PIB结合与MCI患者记忆损伤严重程度之间的密切关系，表明皮质PIB结合增加的个体可能会导致阿尔茨海默病。数据还表明，针对大脑A β沉积的非痴呆个体的AD早期干预试验是有必要的。
beta-amyloid (A beta) deposition is pathognomic for Alzheimer's disease (AD), but may occur in normal elderly people without apparent cognitive effect. Episodic memory impairment is an early and prominent sign of AD, but its relationship with A beta burden in non-demented persons and in AD patients is unclear. We examined this relationship using C-11-PIB-PET as a quantitative marker of A beta burden in vivo in healthy ageing (HA), mild cognitive impairment (MCI) and AD. Thirty-one AD, 33 MCI and 32 HA participants completed neuropsychological assessment and a C-11-PIB-PET brain scan. Multiple linear regression analyses were conducted relating episodic memory performance and other cognitive functions to A beta burden. Ninety-seven percent of AD, 61% of MCI and 22% of HA cases had increased cortical PIB binding, indicating the presence of A beta plaques. There was a strong relationship between impaired episodic memory performance and PIB binding, both in MCI and HA. This relationship was weaker in AD and less robust for non-memory cognitive domains. A beta deposition in the asymptomatic elderly is associated with episodic memory impairment. This finding, together with the strong relationship between PIB binding and the severity of memory impairment in MCI, suggests that individuals with increased cortical PIB binding are on the path to Alzheimer's disease. The data also suggests that early intervention trials for AD targeted to non-demented individuals with cerebral A beta deposition are warranted.