Tau suppression in a neurodegenerative mouse model improves memory function
Tau suppression in a neurodegenerative mouse model improves memory function
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DOI：
10.1126/science.1113694
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发表时间：
2005-07-15
期刊：
影响因子：
56.9
通讯作者：
Ashe, KH
中科院分区：
文献类型：
--
作者：
SantaCruz, K;Lewis, J;Ashe, KH
神经元缠结（NFT）是神经退行性疾病患者脑中最常见的神经元内包涵体，并与介导神经元死亡和认知缺陷有关。在这里，我们发现表达可抑制的人类tau变体的小鼠发展了进行性年龄相关的NFT，神经元损失和行为障碍。在抑制转基因tau蛋白后，记忆功能恢复，神经元数量稳定，但令我们惊讶的是，NFT继续积累。因此，NFT不足以在该tau蛋白病模型中引起认知下降或神经元死亡。
Neurofibrillary tangles (NFTs) are the most common intraneuronal inclusion in the brains of patients with neurodegenerative diseases and have been implicated in mediating, neuronal death and cognitive deficits. Here, we found that mice expressing a repressible human tau variant developed progressive age-related NFTs, neuronal loss, and behavioral impairments. After the suppression of transgenic tau, memory function recovered, and neuron numbers stabilized, but to our surprise, NFTs continued to accumulate. Thus, NFTs are not sufficient to cause cognitive decline or neuronal death in this model of tauopathy.