Mg-II-Catalyzed Desymmetrization Reaction of meso-Aziridines with Hydroxylamines: Synthesis of Novel Chiral 1,2-Diamine Skeletons
Mg-II-Catalyzed Desymmetrization Reaction of meso-Aziridines with Hydroxylamines: Synthesis of Novel Chiral 1,2-Diamine Skeletons
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Mg-II 催化内消旋氮丙啶与羟胺的去对称反应：新型手性 1,2-二胺骨架的合成
DOI：
10.1002/chem.201603898
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Wang Rui
中科院分区：
文献类型：
--
作者：
Li Dan;Yang Dongxu;Wang Linqing;Liu Xihong;Jiang Xianxing;Wang Rui
首次公开了 MgII 催化内消旋氮丙啶与羟胺的去对称反应。以良好的产率和对映选择性获得了一系列新型手性 1,2-二胺骨架。该反应采用由简单的恶唑啉-OH手性配体原位产生的镁催化。显然，所获得的手性1,2-二胺化合物的不同结构可以使它们成为未来催化不对称合成研究中潜在的手性配体。
A MgII‐catalyzed desymmetrization reaction ofmeso‐aziridines with hydroxylamines has been disclosed for the first time. A series of novel chiral 1,2‐diamine skeletons were obtained in good yields and enantioselectivities. The reaction employed magnesium catalysis generated in situ from a simple oxazoline‐OH chiral ligand. Obviously, the diverse structures of the obtained chiral 1,2‐diamine compounds could allow them to be potential chiral ligands in future catalytic asymmetric synthesis studies.