Neuroendocrine effects of leptin.
Neuroendocrine effects of leptin.
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DOI：
10.1023/a:1012930609563
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发表时间：
2001-01-01
期刊：
影响因子：
3.8
通讯作者：
Gaillard, R C
中科院分区：
文献类型：
--
作者：
Pralong, F P;Gaillard, R C
瘦素是肥胖基因的产物，是一种类似精氨酸的循环蛋白，作为外周饱腹信号传递给下丘脑。它最初被描述为白色脂肪细胞的分泌产物，但最近的数据表明其在内分泌和神经内分泌组织（如卵巢和下丘脑）以及几种垂体前叶细胞类型中表达。瘦素对体重稳态的影响是通过不同的下丘脑神经递质调节食欲和能量消耗来介导的。此外，瘦素参与调节神经内分泌促甲状腺激素、促生长激素、促皮质激素和促性腺激素轴的活性。瘦素的这些内分泌作用已逐渐成为该分子的重要生理功能。它作为青春期和成年期正常生殖功能的许可因素的作用正得到广泛承认。此外，瘦素还参与促肾上腺皮质激素轴的微调。因此，通过向下丘脑和其他内分泌器官发出身体脂肪储存的信号，瘦素充当几种神经内分泌功能的代谢整合剂。本文综述了瘦素对促性腺激素和促生长激素轴的作用部位和调节方式。
Leptin, the product of the obesity gene, is a cytokine-like circulating protein acting as a peripheral satiety signal to the hypothalamus. It was initially described as a secreted product of white adipose cells, but more recent data have demonstrated its expression by endocrine and neuroendocrine tissues like the ovary and the hypothalamus, as well as several anterior pituitary cell types. The effects of leptin on body weight homeostasis are mediated via different hypothalamic neurotransmitters regulating appetite and energy expenditure. In addition, leptin participates to the modulation of the activity of the neuroendocrine thyrotrope, somatotrope, corticotrope and gonadotrope axes. These endocrine effects of leptin have progressively emerged as important physiological functions of this molecule. Its role as a permissive factor for puberty and normal reproductive function in adulthood is becoming widely recognized. In addition, leptin participates in the fine tuning of the corticotrope axis. Thus, by signalling body fat stores to the hypothalamus and other endocrine organs, leptin serves as a metabolic integrator of several neuroendocrine functions. The precise site of action and mode of regulation of the gonadotrope and somatotrope axes by leptin are reviewed.