Attention bias modification for major depressive disorder: Effects on attention bias, resting state connectivity, and symptom change.
Attention bias modification for major depressive disorder: Effects on attention bias, resting state connectivity, and symptom change.
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DOI：
10.1037/abn0000049
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发表时间：
2015-08
影响因子：
4.6
通讯作者：
Schnyer DM
中科院分区：
文献类型：
--
作者：
Beevers CG;Clasen PC;Enock PM;Schnyer DM
抑郁的认知理论认为，对负性信息的选择性注意有助于抑郁的维持。目前的研究通过随机分配患有重度抑郁症（MDD）的成年人进行为期四周的基于计算机的注意力偏差修正，旨在减少负面注意力偏差，或进行为期四周的安慰剂注意力训练来验证这一想法。研究结果表明，与安慰剂训练相比，注意力偏差修正减少了负面注意力偏差，增加了神经回路内的静息状态连接（即，额中回和背侧前扣带皮层），支持对情绪信息的控制。此外，只有在主动训练条件下，训练前后的负性注意偏向变化与抑郁症状变化显著相关。探索性分析表明，训练前后与持续关注视觉信息相关的回路内静息状态连接性的变化（即，脑前回和额中回）有助于安慰剂条件下的症状改善。重要的是，抑郁症状在不同的训练组之间并没有不同的变化，总体而言，在注意力训练条件下观察到症状减少了40%。研究结果表明，负性注意力偏差与抑郁症的维持有关;然而，一般注意力控制也可能维持抑郁症症状，如在安慰剂训练条件下的静息状态连接和抑郁症症状改善所证明的那样。
Cognitive theories of depression posit that selective attention for negative information contributes to the maintenance of depression. The current study experimentally tested this idea by randomly assigning adults with Major Depressive Disorder (MDD) to four weeks of computer-based attention bias modification designed to reduce negative attention bias or four weeks of placebo attention training. Findings indicate that compared to placebo training, attention bias modification reduced negative attention bias and increased resting-state connectivity within a neural circuit (i.e., middle frontal gyrus and dorsal anterior cingulate cortex) that supports control over emotional information. Further, pre- to post-training change in negative attention bias was significantly correlated with depression symptom change only in the active training condition. Exploratory analyses indicated that pre- to post-training changes in resting state connectivity within a circuit associated with sustained attention to visual information (i.e., precuenus and middle frontal gyrus) contributed to symptom improvement in the placebo condition. Importantly, depression symptoms did not change differentially between the training groups—overall, a 40% decrease in symptoms was observed across attention training conditions. Findings suggest that negative attention bias is associated with the maintenance of depression; however, general attentional control may also maintain depression symptoms, as evidenced by resting state connectivity and depression symptom improvement in the placebo training condition.