New 19-oxygenated and 4-methylated steroids from the Formosan soft coral Nephthea chabroli
New 19-oxygenated and 4-methylated steroids from the Formosan soft coral Nephthea chabroli
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DOI：
10.1016/j.steroids.2009.02.004
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发表时间：
2009-06-01
期刊：
影响因子：
2.7
通讯作者：
Duh, Chang-Yih
中科院分区：
文献类型：
--
作者：
Cheng, Shi-Yie;Huang, Ya-Chiang;Duh, Chang-Yih
对台湾软珊瑚Nephthea chabroli的化学研究分离出四种新的19-氧合类固醇，nebrosteroid I-L（1-4），以及一种新的4 α-甲基化类固醇，nebrosteroid M（5）。这些分离的代谢产物的分子结构是在广泛的光谱分析的基础上，并通过与相关代谢产物的数据比较来阐明的。使用RAW 264.7巨噬细胞评价化合物1-5的抗炎活性。(C)2009 Elsevier Inc. All rights reserved.
Chemical investigation of the Formosan soft coral Nephthea chabroli resulted in the isolation of four new 19-oxygenated steroids, nebrosteroids I-L(1-4), together with a new 4 alpha-methylated steroid, nebrosteroid M (5). The molecular structures of these isolated metabolites were elucidated on the basis of extensive spectroscopic analysis and by comparison of the data with those of related metabolites. Compounds 1-5 were evaluated for anti-inflammatory activity using RAW 264.7 macrophages. (C) 2009 Elsevier Inc. All rights reserved.