Differences in EEG Delta Frequency Characteristics and Patterns in Slow-Wave Sleep Between Dementia Patients and Controls: A Pilot Study
Differences in EEG Delta Frequency Characteristics and Patterns in Slow-Wave Sleep Between Dementia Patients and Controls: A Pilot Study
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DOI：
10.1097/wnp.0b013e318246b56d
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发表时间：
2012-02-01
影响因子：
2.4
通讯作者：
Ktonas, Periklis Y.
中科院分区：
文献类型：
--
作者：
Bonanni, Enrica;Di Coscio, Elisa;Ktonas, Periklis Y.
目的：利用频谱分析和周期幅度分析，评估痴呆患者与健康老年受试者相比，慢波睡眠期间脑电图活动的变化。方法：对 5 名痴呆患者和 5 名老年对照受试者进行夜间多导睡眠图记录。对于前三个非快速眼动-快速眼动睡眠周期中的每一个，选择明确的慢波睡眠部分。通过频谱分析和周期幅度分析对这些部分的 Delta 频段（0.4-3.6 Hz）进行分析。结果：频谱分析显示痴呆组的 Delta 频段功率有所增加，而仅在对照组中观察到整个夜间的 Delta 频段功率有所下降。对于痴呆症组，周期幅度分析显示，频率低于 1.6 Hz 的明确 δ 波的发生率和幅度有所减少，频率高于 2 Hz 的δ波的发生率和幅度有所增加。结论：我们的研究表明，(1) 痴呆症患者整个夜间睡眠期间 δ 波段功率的动态损失，以及 (2) 与对照组受试者相比，痴呆症患者慢波睡眠期间 δ 波的分布不同。这种基于计算机的分析可以突出痴呆症患者慢波睡眠期间病理性δ活动的存在，并可能支持睡眠改变和认知能力下降之间动态相互作用的假设。
Purpose: To evaluate the modifications of EEG activity during slow-wave sleep in patients with dementia compared with healthy elderly subjects, using spectral analysis and period-amplitude analysis.Methods: Five patients with dementia and 5 elderly control subjects underwent night polysomnographic recordings. For each of the first three nonrapid eye movement-rapid eye movement sleep cycles, a well-defined slow-wave sleep portion was chosen. The delta frequency band (0.4-3.6 Hz) in these portions was analyzed with both spectral analysis and period-amplitude analysis.Results: Spectral analysis showed an increase in the delta band power in the dementia group, with a decrease across the night observed only in the control group. For the dementia group, period-amplitude analysis showed a decrease in well-defined delta waves of frequency lower than 1.6 Hz and an increase in such waves of frequency higher than 2 Hz, in incidence and amplitude.Conclusions: Our study showed (1) a loss of the dynamics of delta band power across the night sleep, in dementia, and (2) a different distribution of delta waves during slow-wave sleep in dementia compared with control subjects. This kind of computer-based analysis can highlight the presence of a pathologic delta activity during slow-wave sleep in dementia and may support the hypothesis of a dynamic interaction between sleep alteration and cognitive decline.