Compensatory reallocation of brain resources supporting verbal episodic memory in Alzheimer's disease
Compensatory reallocation of brain resources supporting verbal episodic memory in Alzheimer's disease
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DOI：
10.1212/wnl.46.3.692
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发表时间：
1996-03-01
期刊：
影响因子：
9.9
通讯作者：
DeKosky, ST
中科院分区：
文献类型：
--
作者：
Becker, JT;Mintun, MA;DeKosky, ST
对具有特定时间和空间背景的过去事件的有意识回忆，称为情景记忆，由相互关联的大脑区域系统介导。在阿尔茨海默病（AD）中，这个系统崩溃，导致无法回忆起最近发生的事件。使用减影技术与PET获得的图像的区域脑血流量，我们表明，AD患者表现出更大的激活大脑皮层的区域通常涉及的记忆-言语记忆，以及激活的皮质区不激活正常的老年人。这些结果提供了明确的证据，在AD患者的大脑中的功能可塑性，即使这些变化不会导致正常的记忆功能，并提供了深入了解AD大脑试图补偿神经变性的机制。
Conscious recall of past events that have specific temporal and spatial contexts, termed episodic memory, is mediated by a system of interrelated brain regions. In Alzheimer's disease (AD) this system breaks down, resulting in an inability to recall events from the immediate past. Using subtraction techniques with PET-acquired images of regional cerebral blood flow, we demonstrate that AD patients show a greater activation of regions of cerebral cortex normally involved in auditory-verbal memory, as well as activation of cortical areas not activated by normal elderly subjects. These results provide clear evidence of functional plasticity in the AD patient's brain even if those changes do not result in normal memory function, and provide insights into the mechanisms by which the AD brain attempts to compensate for neurodegeneration.